Löffler Harald, Steffes Anja, Happle Rudolf, Effendy Isaak
Department of Dermatology, University of Marburg, Germany.
Acta Derm Venereol. 2003;83(5):328-31. doi: 10.1080/00015550310006554.
The pathomechanism of atopic eczema is complex. Two of the most important exogenous factors for atopic eczema are allergenic and irritant substances. In this study we investigate the combined effect of topical aeroallergens and irritation on the skin of atopic individuals. We performed patch testing with several aeroallergens (atopy patch test) and with an irritant, sodium lauryl sulphate, on clinically unaffected skin of 30 sensitized patients with atopic eczema. Application was conducted alone and as a consecutive application. Healthy volunteers served as controls. Evaluation was made by measurement of transepidermal water loss 2 h after removal of the patches. In atopic patients, we found increased levels of transepidermal water loss induced by the aeroallergens as well as by sodium lauryl sulphate. The most impressive barrier disruption was seen after application of house dust mite, followed by cat dander and grass pollen. However, the consecutive application of aeroallergens and sodium lauryl sulphate led to a highly pronounced increase in transepidermal water loss. Hence, in sensitized atopic subjects the combined effect of aeroallergens and detergents may cause severe skin problems, and this may be relevant in daily practice.
特应性皮炎的发病机制复杂。特应性皮炎最重要的两个外源性因素是变应原和刺激性物质。在本研究中，我们调查了局部气源性变应原和刺激对特应性个体皮肤的联合作用。我们对30名患有特应性皮炎的致敏患者临床未受累的皮肤进行了几种气源性变应原的斑贴试验（特应性斑贴试验）以及使用刺激性物质月桂醇硫酸酯钠进行斑贴试验。单独进行应用以及连续应用。健康志愿者作为对照。在去除斑贴2小时后通过测量经表皮水分流失进行评估。在特应性患者中，我们发现气源性变应原以及月桂醇硫酸酯钠均可导致经表皮水分流失增加。应用屋尘螨后观察到最明显的屏障破坏，其次是猫毛屑和草花粉。然而，气源性变应原和月桂醇硫酸酯钠的连续应用导致经表皮水分流失显著增加。因此，在致敏的特应性个体中，气源性变应原和洗涤剂的联合作用可能会导致严重的皮肤问题，这在日常实践中可能具有相关性。
