Kazemekaite M, Talaikyte Z, Udrenaite E, Labanauskas L, Staniulyte Z, Palaima A
Institute of Biochemistry, Vilnius University, Lithuania.
Pharmazie. 2003 Oct;58(10):730-2.
The acute toxicity and anti-inflammatory activity of eleven potassium salts of sulfobenzene and sulfonaphthalene 3,3-disubstituted triazenes have been examined in rats with carrageenin- and bentonite-induced edema using a 50 mg/kg p.o. dose. All compounds were found to exhibit anti-inflammatory activity significantly exceeding that of acetylsalicylic acid and ibuprofen, and were less toxic than these reference drugs. The most pronounced anti-inflammatory activity was shown by the potassium salt of 4-(piperazin-1-ylazo)benzenesulfonic acid.
以50mg/kg的口服剂量，在角叉菜胶和膨润土诱导水肿的大鼠中检测了11种苯磺酸和萘磺酸3,3 - 二取代三氮烯钾盐的急性毒性和抗炎活性。发现所有化合物均表现出显著超过乙酰水杨酸和布洛芬的抗炎活性，且毒性低于这些参比药物。4-(哌嗪-1-基偶氮)苯磺酸钾盐表现出最显著的抗炎活性。
