具有抗炎活性的6,7-二烷氧基-2-芳基亚甲基-2,3-二氢苯并[4,5]咪唑并[2,1-b][1,3]噻唑-3-酮的合成
Synthesis of 6,7-dialkoxy-2-arylmethylidene-2,3- dihydrobenzo[4,5]imidazo[2,1-b][1,3]thiazol-3-ones exhibiting anti-inflammatory activity.
作者信息
Labanauskas L, Brukstus A, Udrenaite E, Gaidelis P, Bucinskaite V, Dauksas V
机构信息
Faculty of Chemistry, Vilnius University, Lithuania.
出版信息
Pharmazie. 2000 Jun;55(6):429-31.
New 6,7-dialkoxy-2-arylmethylidene-2,3- dihydrobenzo[4,5]imidazo[2,1-b][1,3]thiazol-3-ones (3a-h, 4b, c, e, g) were synthesized from 2-(5,6-dialkoxy-1H-benzo[d]imidazol-2-ylsulfanyl)acetic acids (1, 2) and corresponding aromatic aldehydes in acetic anhydride. The compounds 3e, f and 4b, g were also synthesized from corresponding aromatic aldehydes and 6,7-dialkoxy-2,3-dihydrobenzo[4,5]imidazo[2,1-b][1,3]thiazol -3-ones (5, 6) obtained by the cyclization of the acids 1 and 2 in acetic anhydride. The synthesized compounds 3a-h and 4b, c, e, g exhibit anti-inflammatory activity.
新型6,7 - 二烷氧基 - 2 - 芳基亚甲基 - 2,3 - 二氢苯并[4,5]咪唑并[2,1 - b][1,3]噻唑 - 3 - 酮（3a - h、4b、c、e、g）由2 - (5,6 - 二烷氧基 - 1H - 苯并[d]咪唑 - 2 - 基硫烷基)乙酸（1、2）与相应的芳香醛在乙酸酐中合成。化合物3e、f以及4b、g也由相应的芳香醛与通过酸1和2在乙酸酐中环化得到的6,7 - 二烷氧基 - 2,3 - 二氢苯并[4,5]咪唑并[2,1 - b][1,3]噻唑 - 3 - 酮（5、6）合成。合成的化合物3a - h以及4b、c、e、g具有抗炎活性。
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