Stevens Anne M
Immunogenetics Department, Fred Hutchinson Cancer Research Center, PO Box 19024, D2-100, 1100 Fairview Avenue NE, Seattle, WA 98109, USA.
Curr Rheumatol Rep. 2003 Dec;5(6):437-44. doi: 10.1007/s11926-003-0054-0.
A growing number of hematopoietic stem cell transplantation centers have reported that patients with chronic graft versus host disease (GVHD) can develop polymyositis (PM). GVHD-PM is similar to idiopathic PM in signs, symptoms, laboratory values, electromyography, radiography, and histology, suggesting that the two conditions may share a similar mechanism in pathogenesis. In chronic GVHD-PM, interactions between allogeneic donor cells and host cells lead to chronic inflammation. In idiopathic PM, the foreign cells could be partially human leukocyte antigen-matched maternal or fetal cells acquired during pregnancy. Thus, PM can be added to the list of potentially allo-autoimmune diseases in which pregnancy-derived microchimerism may play a role.
越来越多的造血干细胞移植中心报告称，患有慢性移植物抗宿主病（GVHD）的患者可能会患上多发性肌炎（PM）。GVHD相关性PM在体征、症状、实验室检查值、肌电图、影像学及组织学方面与特发性PM相似，这表明这两种病症在发病机制上可能具有相似的机制。在慢性GVHD相关性PM中，异基因供体细胞与宿主细胞之间的相互作用会导致慢性炎症。在特发性PM中，外来细胞可能是孕期获得的部分人类白细胞抗原匹配的母体或胎儿细胞。因此，PM可被列入妊娠源性微嵌合体可能起作用的潜在同种异体自身免疫性疾病名单中。
