Freeman R B
Department of Surgery, Division of Transplantation, New England Medical Center/Tufts University School of Medicine, Boston, Massachusetts 02111, USA.
Transplant Proc. 2003 Nov;35(7):2425-7. doi: 10.1016/j.transproceed.2003.08.015.
The liver allocation policy in the United States was changed on February 27, 2002, to a continuous scale with almost no weight given to time waiting on the list. This was based on the dissatisfaction with the old categorical system and an understanding that waiting time as not a good discriminator of medical urgency. To assess the effects of this change, liver allocation results for the first 6 months of this new system (February 27, 2002, to August 30, 2002, era 2) with the corresponding 6 month period 1 year earlier (February 27, 2001, to August 30, 2001, era 1) were compared. Fewer registrations on the waiting list, fewer removals from the waiting list because of death or "too sick," and an increase in the number of cadaveric transplants under the new system were observed. Patients with hepatocellular cancer received additional priority with the new policy and there was a significant increase in the number of candidates transplanted with this diagnosis in era 2. Early posttransplant patient survival has not changed under the new system. Although there are many areas for improvement, which will be addressed in future refinements, the new US liver allocation plan has provided a more objective, patient-specific system to better rank waiting liver transplant candidates.
2002年2月27日,美国的肝脏分配政策发生了变化,采用了一种连续评分系统,几乎不再考虑患者在等待名单上的等待时间。这是基于对旧的分类系统的不满,以及认识到等待时间并不能很好地区分医疗紧急程度。为了评估这一变化的影响,对新系统的前6个月(2002年2月27日至2002年8月30日,第2阶段)与一年前相应的6个月期间(2001年2月27日至2001年8月30日,第1阶段)的肝脏分配结果进行了比较。结果发现,新系统下等待名单上的登记人数减少,因死亡或“病情过重”而从等待名单上移除的人数减少,尸体肝移植数量增加。肝细胞癌患者在新政策下获得了额外的优先权,在第2阶段,因该诊断而接受移植的候选者数量显著增加。新系统下移植后早期患者生存率没有变化。尽管仍有许多需要改进的地方,将在未来的改进中加以解决,但美国新的肝脏分配计划提供了一个更客观、针对患者的系统,以便更好地对等待肝移植的候选者进行排序。