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分流术后的生存情况及曲张静脉再出血支持小口径人工血管H型门腔分流术。

Survival and variceal rehemorrhage after shunting support small-diameter prosthetic H-graft portacaval shunt.

作者信息

Rosemurgy Alexander, Thometz Donald, Clark Whalen, Villadolid Desiree, Carey Elizabeth, Pinkas Daphne, Rakita Steven, Zervos Emmanuel

机构信息

Department of Surgery, University of South Florida College of Medicine, Tampa, FL 33601, USA.

出版信息

J Gastrointest Surg. 2007 Mar;11(3):325-32. doi: 10.1007/s11605-006-0056-0.

Abstract

This study was undertaken to report variceal rebleeding and survival after small-diameter prosthetic H-graft portacaval shunts (HGPCS) and to compare actual to predicted survival after shunting. Since 1987 we have prospectively followed patients after undergoing HGPCS to treat bleeding varices failing/not amenable to sclerotherapy/banding. One hundred and seventy patients underwent shunting. Cirrhosis was because of alcohol in 56%, hepatitis in 12%, both in 11%, and other causes in 21%. Child class was A for 10%, B for 28%, and C for 62%. Thirty-three patients died by 6 months, 54 by 24 months, 87 by 60 months, and 112 by 10 years, generally because of liver failure. Fifty-one patients are alive at a median of 48.3 months, 76 months +/- 57.8 (mean +/- SD). Variceal rehemorrhage was documented in 3 (2%) patients. By child class, 5-year/10-year survival rates were as follows: A 66.7/33.3%, B 48.6/15.6%, and C 29.2/7.0%. Actual survival was superior to predicted survival (Model for End-Stage Liver Disease [MELD]), (p < 0.001). Variceal rehemorrhage in patients undergoing small-diameter prosthetic H-graft portacaval shunting was very uncommon. Actual survival was superior to predicted survival (MELD). Long-term survival paralleled degree of hepatic function, although long-term survival was possible even with very advanced cirrhosis. Application of HGPCS is encouraged.

摘要

本研究旨在报告小口径人工血管H型门腔分流术(HGPCS)后静脉曲张再出血情况及生存率,并比较分流术后实际生存率与预测生存率。自1987年以来,我们对接受HGPCS治疗静脉曲张出血但硬化治疗/套扎术失败或不适用的患者进行了前瞻性随访。170例患者接受了分流术。肝硬化病因中,酒精性占56%,肝炎占12%,酒精和肝炎均占11%,其他原因占21%。Child分级为A的占10%,B的占28%,C的占62%。33例患者在6个月内死亡,54例在24个月内死亡,87例在60个月内死亡,112例在10年内死亡,主要死因是肝功能衰竭。51例患者存活,中位生存期为48.3个月,76个月±57.8(均值±标准差)。3例(2%)患者记录到静脉曲张再出血。按Child分级,5年/10年生存率如下:A为66.7%/33.3%,B为48.6%/15.6%,C为29.2%/7.0%。实际生存率优于预测生存率(终末期肝病模型[MELD]),(p<0.001)。接受小口径人工血管H型门腔分流术患者的静脉曲张再出血非常少见。实际生存率优于预测生存率(MELD)。长期生存率与肝功能程度平行,尽管即使是非常晚期的肝硬化患者也有可能长期存活。鼓励应用HGPCS。

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