Rosemurgy Alexander, Thometz Donald, Clark Whalen, Villadolid Desiree, Carey Elizabeth, Pinkas Daphne, Rakita Steven, Zervos Emmanuel
Department of Surgery, University of South Florida College of Medicine, Tampa, FL 33601, USA.
J Gastrointest Surg. 2007 Mar;11(3):325-32. doi: 10.1007/s11605-006-0056-0.
This study was undertaken to report variceal rebleeding and survival after small-diameter prosthetic H-graft portacaval shunts (HGPCS) and to compare actual to predicted survival after shunting. Since 1987 we have prospectively followed patients after undergoing HGPCS to treat bleeding varices failing/not amenable to sclerotherapy/banding. One hundred and seventy patients underwent shunting. Cirrhosis was because of alcohol in 56%, hepatitis in 12%, both in 11%, and other causes in 21%. Child class was A for 10%, B for 28%, and C for 62%. Thirty-three patients died by 6 months, 54 by 24 months, 87 by 60 months, and 112 by 10 years, generally because of liver failure. Fifty-one patients are alive at a median of 48.3 months, 76 months +/- 57.8 (mean +/- SD). Variceal rehemorrhage was documented in 3 (2%) patients. By child class, 5-year/10-year survival rates were as follows: A 66.7/33.3%, B 48.6/15.6%, and C 29.2/7.0%. Actual survival was superior to predicted survival (Model for End-Stage Liver Disease [MELD]), (p < 0.001). Variceal rehemorrhage in patients undergoing small-diameter prosthetic H-graft portacaval shunting was very uncommon. Actual survival was superior to predicted survival (MELD). Long-term survival paralleled degree of hepatic function, although long-term survival was possible even with very advanced cirrhosis. Application of HGPCS is encouraged.
本研究旨在报告小口径人工血管H型门腔分流术(HGPCS)后静脉曲张再出血情况及生存率,并比较分流术后实际生存率与预测生存率。自1987年以来,我们对接受HGPCS治疗静脉曲张出血但硬化治疗/套扎术失败或不适用的患者进行了前瞻性随访。170例患者接受了分流术。肝硬化病因中,酒精性占56%,肝炎占12%,酒精和肝炎均占11%,其他原因占21%。Child分级为A的占10%,B的占28%,C的占62%。33例患者在6个月内死亡,54例在24个月内死亡,87例在60个月内死亡,112例在10年内死亡,主要死因是肝功能衰竭。51例患者存活,中位生存期为48.3个月,76个月±57.8(均值±标准差)。3例(2%)患者记录到静脉曲张再出血。按Child分级,5年/10年生存率如下:A为66.7%/33.3%,B为48.6%/15.6%,C为29.2%/7.0%。实际生存率优于预测生存率(终末期肝病模型[MELD]),(p<0.001)。接受小口径人工血管H型门腔分流术患者的静脉曲张再出血非常少见。实际生存率优于预测生存率(MELD)。长期生存率与肝功能程度平行,尽管即使是非常晚期的肝硬化患者也有可能长期存活。鼓励应用HGPCS。