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通过用苯基氯化镁还原官能化硝基芳烃来温和合成多官能团苯并咪唑和吲哚。

Mild synthesis of polyfunctional benzimidazoles and indoles by the reduction of functionalized nitroarenes with phenylmagnesium chloride.

作者信息

Dohle Wolfgang, Staubitz Anne, Knochel Paul

机构信息

Department Chemie, Ludwig-Maximilians-Universität, Butenandtstrasse 5 - 13, Haus F, 81377 München, Germany.

出版信息

Chemistry. 2003 Nov 7;9(21):5323-31. doi: 10.1002/chem.200305090.

DOI:10.1002/chem.200305090
PMID:14613142
Abstract

Phenylmagnesium chloride has been used for the conversion of selected nitroarenes into nitrenes. Their insertion into a neighboring sp(2) C-H bond yielded functionalized heterocycles. A novel and mild synthesis of polyfunctional benzimidazoles and indoles is described.

摘要

苯基氯化镁已被用于将选定的硝基芳烃转化为氮烯。它们插入相邻的sp(2) C-H键生成了功能化杂环。本文描述了一种新型温和的多官能团苯并咪唑和吲哚的合成方法。

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