Lindholm M
Dept of Anaesthesia and Intensive Care, Huddinge University Hospital, Karolinska Institute, Sweden.
Minerva Anestesiol. 1992 Oct;58(10):875-9.
In critically ill patients, lipid tolerance may be impaired. In ICU, patients are usually given TPN including fat emulsions. If sedation with propofol is given simultaneously the fat load increases and may exceed the maximal clearing capacity of exogenous fat emulsion unless the administration of the parenteral fat is adjusted to take account of the lipid contained in propofol. An accumulation of fat may result in the so-called 'fat overload syndrome'. Close monitoring of serum triglyceride concentration is therefore recommended to avoid fat overload.
在重症患者中，脂质耐受性可能受损。在重症监护病房（ICU），患者通常接受包括脂肪乳剂在内的全胃肠外营养（TPN）。如果同时给予丙泊酚镇静，脂肪负荷会增加，可能会超过外源性脂肪乳剂的最大清除能力，除非调整肠外脂肪的给药量以考虑丙泊酚中所含的脂质。脂肪堆积可能导致所谓的“脂肪超载综合征”。因此，建议密切监测血清甘油三酯浓度以避免脂肪超载。
