Lee Laura A, Orr-Weaver Terry L
Whitehead Institute and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.
Annu Rev Genet. 2003;37:545-78. doi: 10.1146/annurev.genet.37.110801.143149.
An intriguing aspect of cell cycle regulation is how cell growth and division are coordinated with developmental signals to produce properly patterned organisms of the appropriate size. Using the foundation laid by a detailed understanding of the regulators that intrinsically control progression through the cell cycle, links between developmental signals and the cell cycle are being elucidated. Considerable progress has been made using Drosophila melanogaster, both in identifying new cell cycle regulators that respond to developmental cues and in defining the impact of extrinsic signals on homologs of mammalian oncogenes and tumor suppressors. In this review, we discuss each cell cycle phase, highlighting differences between archetypal and variant cell cycles employed for specific developmental strategies. We emphasize the interplay between developmental signals and cell cycle transitions. Developmental control of checkpoints, cell cycle exit, and cell growth are also addressed.
细胞周期调控中一个引人入胜的方面是，细胞生长和分裂如何与发育信号协调，以产生大小合适、模式正确的生物体。基于对内在控制细胞周期进程的调节因子的详细了解所奠定的基础，发育信号与细胞周期之间的联系正在被阐明。利用黑腹果蝇已取得了相当大的进展，这体现在识别出响应发育线索的新细胞周期调节因子，以及确定外在信号对哺乳动物癌基因和肿瘤抑制因子同源物的影响。在本综述中，我们讨论细胞周期的各个阶段，突出用于特定发育策略的典型细胞周期和变体细胞周期之间的差异。我们强调发育信号与细胞周期转换之间的相互作用。还讨论了关卡、细胞周期退出和细胞生长的发育控制。
