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Dme-Hsa 疾病数据库 (DHDD)：. 中保守的人类疾病相关 miRNA 及其靶基因

Dme-Hsa Disease Database (DHDD): Conserved Human Disease-Related miRNA and Their Targeting Genes in .

机构信息

Laboratory for Comparative Genomics and Bioinformatics & Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Science, Nanjing Normal University, Nanjing 210046, Jiangsu, China.

School of Life Sciences, School of Ocean Nantong University, Nantong 226019, Jiangsu, China.

出版信息

Int J Mol Sci. 2018 Sep 6;19(9):2642. doi: 10.3390/ijms19092642.

DOI:10.3390/ijms19092642
PMID:30200613
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6163619/
Abstract

Abnormal expressions of microRNA (miRNA) can result in human diseases such as cancer and neurodegenerative diseases. MiRNA mainly exert their biological functions via repressing the expression of their target genes. () is an ideal model for studying the molecular mechanisms behind biological phenotypes, including human diseases. In this study, we collected human and miRNA as well as known human disease-related genes. In total, we identified 136 human disease-related miRNA that are orthologous to 83 miRNA by mapping "seed sequence", and 677 human disease-related genes that are orthologous to 734 genes using the DRSC Integrative Ortholog Prediction Tool Furthermore, we revealed the target relationship between genes and miRNA using miRTarBase database and target prediction software, including miRanda and TargetScan. In addition, we visualized interaction networks and signalling pathways for these filtered miRNA and target genes. Finally, we compiled all the above data and information to generate a database designated DHDD This is the first comprehensive collection of human disease-related miRNA and their targeting genes conserved in a database. The DHDD provides a resource for easily searching human disease-related miRNA and their disease-related target genes as well as their orthologs in , and conveniently identifying the regulatory relationships among them in the form of a visual network.

摘要

异常表达的 microRNA (miRNA) 可能导致人类疾病，如癌症和神经退行性疾病。miRNA 主要通过抑制其靶基因的表达来发挥其生物学功能。（）是研究包括人类疾病在内的生物学表型背后的分子机制的理想模型。在这项研究中，我们收集了人类和 miRNA 以及已知与人类疾病相关的基因。通过“种子序列”映射，我们总共鉴定出 136 种与 83 种 miRNA 同源的人类疾病相关 miRNA，通过使用 DRSC 综合同源物预测工具，我们鉴定出 677 种与 734 种基因同源的人类疾病相关基因。此外，我们使用 miRTarBase 数据库和靶标预测软件，包括 miRanda 和 TargetScan，揭示了基因和 miRNA 之间的靶标关系。此外，我们可视化了这些筛选出的 miRNA 和靶基因的相互作用网络和信号通路。最后，我们将所有上述数据和信息汇编成一个数据库，命名为 DHDD。这是第一个在 数据库中全面收集人类疾病相关 miRNA 及其保守靶基因的数据库。DHDD 提供了一个资源，方便搜索人类疾病相关 miRNA 及其疾病相关靶基因及其在 中的同源物，并以可视化网络的形式方便地识别它们之间的调控关系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e37a/6163619/eb90a3df3004/ijms-19-02642-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e37a/6163619/38f8182f9bff/ijms-19-02642-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e37a/6163619/aa94e49dbce1/ijms-19-02642-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e37a/6163619/b661cf5aef33/ijms-19-02642-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e37a/6163619/eb90a3df3004/ijms-19-02642-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e37a/6163619/38f8182f9bff/ijms-19-02642-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e37a/6163619/aa94e49dbce1/ijms-19-02642-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e37a/6163619/b661cf5aef33/ijms-19-02642-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e37a/6163619/eb90a3df3004/ijms-19-02642-g004.jpg

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