Brusic V, Petrovsky N, Gendel S M, Millot M, Gigonzac O, Stelman S J
Institute for Infocomm Research, Singapore.
Allergy. 2003 Nov;58(11):1083-92. doi: 10.1034/j.1398-9995.2003.00224.x.
Allergy is a major cause of morbidity worldwide. The number of characterized allergens and related information is increasing rapidly creating demands for advanced information storage, retrieval and analysis. Bioinformatics provides useful tools for analysing allergens and these are complementary to traditional laboratory techniques for the study of allergens. Specific applications include structural analysis of allergens, identification of B- and T-cell epitopes, assessment of allergenicity and cross-reactivity, and genome analysis. In this paper, the most important bioinformatic tools and methods with relevance to the study of allergy have been reviewed.
过敏是全球发病的主要原因。已鉴定的过敏原数量和相关信息正在迅速增加，这对先进的信息存储、检索和分析提出了需求。生物信息学为分析过敏原提供了有用的工具，这些工具是对研究过敏原的传统实验室技术的补充。具体应用包括过敏原的结构分析、B细胞和T细胞表位的鉴定、致敏性和交叉反应性评估以及基因组分析。本文综述了与过敏研究相关的最重要的生物信息学工具和方法。
