Heckmayr M, Gatzemeier U
Department of Thoracic Oncology, Hospital Grosshansdorf, Hamburg, FRG.
Oncology. 1992;49 Suppl 2:32-4. doi: 10.1159/000227125.
Megestrol acetate, a semisynthetic gestagen, is effective not only for endocrine therapy of advanced breast carcinomas, but also in the treatment of cachectic patients with aggressive, hormone-independent tumors. Sixty-six patients with therapy-resistant, advanced bronchogenic carcinomas of different histologic types, who had lost more than 10% of their regular body weight within a prospective, randomized trial, were treated with megestrol acetate at a dose of either 160 or 480 mg/day for 3-4 months. The mean weight gain for all patients was 2.5 kg. Nearly all of them (80%) reported improved appetite and well-being. The mean weight gain in the group of patients receiving 480 mg/day was higher (3.0 kg) than in the group receiving 160 mg/day (2.0 kg).
醋酸甲地孕酮是一种半合成孕激素，不仅对晚期乳腺癌的内分泌治疗有效，而且对患有侵袭性、激素非依赖性肿瘤的恶病质患者也有治疗作用。在一项前瞻性随机试验中，66例不同组织学类型的治疗抵抗性晚期支气管癌患者，体重下降超过正常体重10%，接受醋酸甲地孕酮治疗，剂量为每日160或480毫克，持续3 - 4个月。所有患者的平均体重增加2.5千克。几乎所有患者（80%）均表示食欲和健康状况有所改善。接受每日480毫克治疗的患者组平均体重增加（3.0千克）高于接受每日160毫克治疗的患者组（2.0千克）。
