Reiber H, Walther K, Althaus H
Neurochemisches Labor, Universität Göttingen, Goettingen, Germany.
Acta Neurol Scand. 2003 Nov;108(5):359-62. doi: 10.1034/j.1600-0404.2003.00173.x.
Beta-trace protein concentrations in cerebrospinal fluid (CSF), serum and nasal secretions are investigated with a new quantitative, immunonephelometric assay.
The mean beta-trace concentration of normal lumbar CSF (18.4 mg/l) and normal serum (0.59 mg/l), from n = 132 control patients, were 10% higher than reported earlier for smaller control groups. The reference range of beta-trace protein in nasal secretions is very low (median: 0.016 mg/l, range <0.003-0.12 mg/l, for n = 29 controls). Clinically confirmed cases of CSF rhinorhea (n = 20) showed beta-trace concentrations between 0.36 and 53.6 mg/l, with a median of 2.4 mg/l. We propose a cut-off value of 0.35 mg/l above which a CSF contamination in the secretion is plausible. A clinically confirmed CSF otorhea had a value of 1.75 mg/l.
This new beta-trace protein assay offers a fast, sensitive and reliable routine method to detect a CSF rhinorhea or otorhea.
采用一种新的定量免疫比浊法检测脑脊液（CSF）、血清和鼻分泌物中的β-微球蛋白浓度。
132例对照患者的正常腰段脑脊液（18.4mg/L）和正常血清（0.59mg/L）中β-微球蛋白的平均浓度比之前较小对照组报告的结果高10%。鼻分泌物中β-微球蛋白的参考范围非常低（中位数：0.016mg/L，范围<0.003-0.12mg/L，n=29例对照）。临床确诊的脑脊液鼻漏病例（n=20）显示β-微球蛋白浓度在0.36至53.6mg/L之间，中位数为2.4mg/L。我们提出0.35mg/L的临界值，高于此值分泌物中脑脊液污染的可能性较大。临床确诊的脑脊液耳漏病例的值为1.75mg/L。
这种新的β-微球蛋白检测方法为检测脑脊液鼻漏或耳漏提供了一种快速、灵敏且可靠的常规方法。
