Harrison Shannon, Sinclair Rodney
Department of Medicine (Dermatology), St Vincent's Hospital Melbourne, Victoria, Australia.
Australas J Dermatol. 2003 Nov;44(4):281-3. doi: 10.1046/j.1440-0960.2003.00010.x.
A 77-year-old woman with a large porokeratosis of Mibelli on the left shin was successfully treated with topical 5% imiquimod cream applied to the entire lesion once daily without occlusion three times a week. A strong inflammatory reaction was achieved in 6 weeks of treatment. The lesion had been present for approximately 6 years and prior treatments included curettage and electrocautery, cryotherapy and topical 5-fluorouracil under occlusion. At the end of treatment with topical 5% imiquimod cream, punch biopsy was negative for porokeratosis. The lesion healed without scarring. At 24-month follow up there had been no sign of clinical recurrence.
一名77岁女性，左小腿患有大面积米贝利汗孔角化症，每周三次每天一次将5%咪喹莫特乳膏外用至整个皮损处，不封包，成功治愈。治疗6周后出现强烈炎症反应。该皮损已存在约6年，既往治疗包括刮除术和电灼术、冷冻疗法以及封包下外用5-氟尿嘧啶。外用5%咪喹莫特乳膏治疗结束时，打孔活检显示汗孔角化症呈阴性。皮损愈合且无瘢痕形成。在24个月的随访中，无临床复发迹象。
