Dubreuil L, Behra-Miellet J, Neut C, Calvet L
Clinical Bacteriology Department, Faculté de Pharmacie, BP83, 59006 Lille CEDEX, France.
Clin Microbiol Infect. 2003 Nov;9(11):1133-8. doi: 10.1046/j.1469-0691.2003.00773.x.
The activity of gatifloxacin, a new fluoroquinolone derivative, was compared with the activities of ciprofloxacin, levofloxacin, amoxicillin, amoxicillin-clavulanate, imipenem, clindamycin and metronidazole against 204 anaerobes isolated from clinical specimens, by MIC determination, using the reference agar dilution method. When determining the overall activity against anaerobes, the MIC50/90 (mg/L) values were amoxicillin 16/>64, amoxicillin-clavulanate 0.125/1, imipenem 0.25/0.5, clindamycin 0.5/>256, metronidazole 1/8, ciprofloxacin 2/32, levofloxacin 1/8 and gatifloxacin 0.5/4. The broad in vitro spectrum of gatifloxacin is promising for the treatment of mixed anaerobic infections, especially those of the respiratory tract, ear, sinus, skin and soft tissues, and bite wounds. These data suggest that gatifloxacin may have a clinical role in the treatment of infections in which anaerobic pathogens are involved.
采用参考琼脂稀释法通过测定最低抑菌浓度（MIC），比较了新型氟喹诺酮衍生物加替沙星与环丙沙星、左氧氟沙星、阿莫西林、阿莫西林-克拉维酸、亚胺培南、克林霉素和甲硝唑对从临床标本中分离出的204株厌氧菌的活性。在测定对厌氧菌的总体活性时，MIC50/90（mg/L）值分别为：阿莫西林16/>64、阿莫西林-克拉维酸0.125/1、亚胺培南0.25/0.5、克林霉素0.5/>256、甲硝唑1/8、环丙沙星2/32、左氧氟沙星1/8和加替沙星0.5/4。加替沙星广泛的体外抗菌谱对于治疗混合性厌氧菌感染，尤其是呼吸道、耳、鼻窦、皮肤和软组织以及咬伤伤口的感染很有前景。这些数据表明，加替沙星在治疗涉及厌氧病原体的感染中可能具有临床作用。
