加替沙星与其他七种药物对厌氧菌的活性比较。
Activities of gatifloxacin compared to those of seven other agents against anaerobic organisms.
作者信息
Ednie L M, Jacobs M R, Appelbaum P C
机构信息
Department of Pathology (Clinical Microbiology), Hershey Medical Center, Hershey, Pennsylvania 17033, USA.
出版信息
Antimicrob Agents Chemother. 1998 Sep;42(9):2459-62. doi: 10.1128/AAC.42.9.2459.
Abstract
The agar dilution MIC was used to compare activities of gatifloxacin with those of ciprofloxacin, sparfloxacin, trovafloxacin, ampicillin, ampicillin-sulbactam, clindamycin, and metronidazole against 351 anaerobes. Overall MICs at which 50% of the isolates are inhibited and MICs at which 90% of the isolates are inhibited (in micrograms per milliliter) were as follows: gatifloxacin, 0.5 and 4; ciprofloxacin, 2 and 32; sparfloxacin, 2 and 8; trovafloxacin, 1 and 4; ampicillin, 1 and 64; ampicillin-sulbactam, 0.5 and 4; clindamycin, 0.125 and 8; and metronidazole, 1 and >16, respectively. Gatifloxacin MICs were similar to those of trovafloxacin in all organism groups.
摘要
采用琼脂稀释法测定最低抑菌浓度（MIC），以比较加替沙星与环丙沙星、司帕沙星、曲伐沙星、氨苄西林、氨苄西林-舒巴坦、克林霉素和甲硝唑对351株厌氧菌的抗菌活性。使50%的分离株被抑制的总体MIC以及使90%的分离株被抑制的MIC（以微克/毫升计）如下：加替沙星，0.5和4；环丙沙星，2和32；司帕沙星，2和8；曲伐沙星，1和4；氨苄西林，1和64；氨苄西林-舒巴坦，0.5和4；克林霉素，0.125和8；甲硝唑，1和>16。在所有菌群中，加替沙星的MIC与曲伐沙星相似。
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