Coppens I, Ter Kuile B H, Opperdoes F R
Cell Biology Unit, University of Louvain Medical School, Brussels, Belgium.
Parasitology. 1992 Dec;105 ( Pt 3):393-8. doi: 10.1017/s0031182000074564.
Cells of Leishmania donovani in co-culture with Trypanosoma brucei, were severely affected in their growth, resulting in swelling and subsequent lysis. Similar effects were also observed when Crithidia luciliae or Phytomonas sp. were co-cultured with T. brucei. Direct contact between the cells under investigation and T. brucei was necessary because T. brucei did not hamper the growth of the other trypanosomatids, when separated by a filter with 0.2 microns pore size. Examination of this phenomenon at the ultrastructural level, in a co-culture of L. donovani and T. brucei, suggests that the plasma membrane permeability is increased in the former, as a result of a close cellular contact between the two cell types.
与布氏锥虫共培养的杜氏利什曼原虫细胞，其生长受到严重影响，导致肿胀并随后裂解。当鲁氏克瑞滴虫或植滴虫与布氏锥虫共培养时，也观察到类似的效果。被研究的细胞与布氏锥虫之间的直接接触是必要的，因为当用孔径为0.2微米的滤膜隔开时，布氏锥虫不会阻碍其他锥虫的生长。在杜氏利什曼原虫和布氏锥虫的共培养物中，在超微结构水平上对这一现象的研究表明，由于两种细胞类型之间紧密的细胞接触，前者的质膜通透性增加。
