Bager P, Rostgaard K, Nielsen N M, Melbye M, Westergaard T
Department of Epidemiology Research, Danish Epidemiology Science Centre, Statens Serum Institut, Copenhagen, Denmark.
Clin Exp Allergy. 2003 Nov;33(11):1512-7. doi: 10.1046/j.1365-2222.2003.01796.x.
It has been proposed that early age at bacille Calmette-Guérin (BCG) vaccination protects against the development of allergy.
To study whether early age at BCG vaccination was associated with a decreased risk of atopy, allergic rhinitis, and asthma compared to BCG vaccination at later ages in childhood.
The occurrence of atopy, allergic rhinitis, and asthma was studied in nearly 2000 women participating in the Danish National Birth Cohort study. Detailed information on age at BCG vaccination (age 0-15 years) was available from school health records. Atopic status was assessed serologically by a specific response to 11 common inhalant allergens using serum samples obtained from the women during the period 1997-2001. Information on allergic rhinitis and asthma was available from telephone interviews.
Approximately 85% of the women had been BCG-vaccinated. Age at BCG vaccination was not associated with risk of atopy, allergic rhinitis, or asthma. The odds ratio of atopy, allergic rhinitis, and asthma associated with being vaccinated during the first year of life was 1.05 (95% CI 0.71-1.56), 1.42 (95% CI 0.85-2.36), and 1.71 (95% CI 0.91-3.20), respectively, compared with being vaccinated at the age of 7 years. Adjustment for birth cohort, sibship size, age of the woman's mother at birth, and social class in childhood did not affect the results.
Our findings suggest that age at BCG vaccination in childhood does not influence the development of allergy or asthma.
有人提出，卡介苗（BCG）接种年龄较早可预防过敏的发生。
研究与儿童期较晚接种卡介苗相比，较早接种卡介苗是否与特应性、过敏性鼻炎和哮喘的风险降低有关。
在参与丹麦国家出生队列研究的近2000名女性中研究了特应性、过敏性鼻炎和哮喘的发生情况。卡介苗接种年龄（0至15岁）的详细信息可从学校健康记录中获得。通过对11种常见吸入性过敏原的特异性反应，使用1997年至2001年期间从这些女性身上采集的血清样本进行血清学评估特应性状态。过敏性鼻炎和哮喘的信息可通过电话访谈获得。
约85%的女性接种了卡介苗。卡介苗接种年龄与特应性、过敏性鼻炎或哮喘的风险无关。与7岁时接种卡介苗相比，出生后第一年接种卡介苗与特应性、过敏性鼻炎和哮喘相关的比值比分别为1.05（95%可信区间0.71 - 1.56）、1.42（95%可信区间0.85 - 2.36）和1.71（95%可信区间0.91 - 3.20）。对出生队列、同胞数量、女性母亲的生育年龄和儿童期社会阶层进行调整后，结果不受影响。
我们的研究结果表明，儿童期卡介苗接种年龄不影响过敏或哮喘的发生。
