Marchant A, Goldman M
Institute for Medical Immunology, Université Libre de Bruxelles, Gosselies, Belgium.
Clin Exp Immunol. 2005 Jul;141(1):10-8. doi: 10.1111/j.1365-2249.2005.02799.x.
Infections with intracellular pathogens are often more severe or more prolonged in young infants suggesting that T cell-mediated immune responses are different in early life. Whereas neonatal immune responses have been quite extensively studied in murine models, studies of T cell-mediated immunity in human newborns and infants are scarce. Qualitative and quantitative differences when compared with adult immune responses have been observed but on the other hand mature responses to certain vaccines and infectious pathogens were demonstrated during the postnatal period and even during foetal life. Herein, we review the evidence suggesting that under appropriate conditions of stimulation, protective T cell-mediated immune responses could be induced by vaccines in early life.
细胞内病原体感染在幼儿中往往更为严重或持续时间更长,这表明T细胞介导的免疫反应在生命早期有所不同。虽然在小鼠模型中对新生儿免疫反应进行了相当广泛的研究,但对人类新生儿和婴儿T细胞介导免疫的研究却很少。与成人免疫反应相比,已观察到定性和定量的差异,但另一方面,在出生后甚至胎儿期就已证明对某些疫苗和感染性病原体有成熟的反应。在此,我们综述了相关证据,表明在适当的刺激条件下,疫苗可在生命早期诱导保护性T细胞介导的免疫反应。