Giustardi A, Coppola G
Clinica Nostra Signora di Lourdes, Massa di Somma, Napoli, Italia.
Pediatr Med Chir. 1992 Jul-Aug;14(4):447-9.
The amoxicillin is a drug that for the incomplete capacity of intestinal absorption in newborn is give for intravenous way. The use of this way and the duration of treatment impose the separation of the newborn from mother and a proportionate preparation of the nurses for the execution of this therapy. We have compared, in newborn infants, with clinical and laboratory diagnosis of neonatal infection, the amoxicillin's plasmatic concentration after intravenous giving and oral giving, in relation to minimum inhibiting concentration the bacteria cause of neonatal infections. In our study (duration 10 months) the newborn infants were perfectly comparable for gestational age, Apgar's score, birthweight, breastfeeding. The newborn infants, at random, were divided in two groups; the first group (18 newborns) received drug for oral way, the second group (14 newborns) for intravenous way. The dosage was 40 mg/Kg/dose of amoxicillin. The duration of treatment was 4 days. Remarkable was the great individual variability of plasmatic concentration of amoxicillin independently from way of giving. The plasmatic concentrations were nearly similar except for the first half hour (plasmatic concentrations after oral giving was lower). The use of oral way is, therefore, favourable for the facility of giving and effective as the intravenous way in the control of neonatal infections.
阿莫西林是一种因新生儿肠道吸收能力不完善而需通过静脉途径给药的药物。这种给药方式及治疗持续时间使得新生儿需与母亲分离，且护士需进行相应准备以实施该治疗。我们针对新生儿感染的临床和实验室诊断，比较了静脉给药和口服给药后阿莫西林的血浆浓度与引起新生儿感染的细菌最低抑菌浓度的关系。在我们为期10个月的研究中，新生儿在胎龄、阿氏评分、出生体重、母乳喂养方面具有良好的可比性。新生儿被随机分为两组；第一组（18名新生儿）接受口服给药，第二组（14名新生儿）接受静脉给药。剂量为每剂量40mg/kg的阿莫西林。治疗持续时间为4天。值得注意的是，阿莫西林血浆浓度存在很大的个体差异，与给药方式无关。除前半小时外，血浆浓度几乎相似（口服给药后的血浆浓度较低）。因此，口服给药方式便于给药，在控制新生儿感染方面与静脉给药方式一样有效。
