Velziene Saule, Kalveniene Zenona, Aleknaviciene Birute, Vaiciuleniene Julija, Savickas Arūnas, Masteiková Rūta
Department of Drug Technology and Pharmaceutical Management, Faculty of Pharmacy, Kaunas University of Medicine, Kaunas, Lithuania.
Medicina (Kaunas). 2003;39 Suppl 2:122-6.
The article deals with the development of technology for production of tablets containing dry herbal extracts. Dry herbal extracts of two different compositions were produced by spray drying using BUCHI 190 apparatus. The quality of dry extracts was evaluated by determination the loss of extract mass during the drying process, and estimation of the amount of biologically active combinations. The tableting methods for dry herbal extracts--direct compression and also employing granulation--were used. The quality of the produced tablets was determined by examining their appearance, resistance to abrasion, crushing strength, mass uniformity, disintegration time. Contents of biologically active compounds in tablets were evaluated by the quantitative methods.
本文论述了含干草药提取物片剂的生产技术发展。使用布奇190设备通过喷雾干燥制备了两种不同成分的干草药提取物。通过测定干燥过程中提取物质量的损失以及评估生物活性成分的含量来评价干提取物的质量。采用了干草药提取物的压片方法——直接压片法以及制粒压片法。通过检查所生产片剂的外观、耐磨性能、抗压强度、质量均匀性、崩解时间来确定其质量。采用定量方法评估片剂中生物活性化合物的含量。
