Sacchini C, El-Sheikhah A, Cicero S, Rembouskos G, Nicolaides K H
Harris Birthright Research Centre for Fetal Medicine, King's College Hospital Medical School, London, UK.
Ultrasound Obstet Gynecol. 2003 Nov;22(5):460-3. doi: 10.1002/uog.903.
To determine the value of measuring fetal ear length at 11-14 weeks of gestation in screening for chromosomal defects.
The fetal ear length was measured in 450 fetuses immediately before chorionic villus sampling for karyotyping at 11-14 weeks of gestation.
The median gestational age was 12 (range, 11-14) weeks. The fetal ear was successfully examined in all cases. The fetal karyotype was normal in 409 cases and abnormal in 41, including 32 cases of trisomy 21. In the chromosomally normal group the fetal ear length increased significantly with crown-rump length from a mean of 3.7 mm at 45 mm to 6.9 mm at 84 mm. In the trisomy 21 fetuses the median ear length was significantly below the normal mean for crown-rump length by 0.45 mm (P = 0.013) but it was below the 5(th) centile of the normal range in only two (6.3%) of the cases. There was no significant association between the delta score of ear length and delta nuchal translucency in either the chromosomally normal (r = - 0.015, P = 0.753) or the trisomy 21 fetuses (r = - 0.014, P = 0.94).
At 11-14 weeks of gestation the ear length in trisomy 21 fetuses is significantly reduced but the degree of deviation from normal is too small for this measurement to be useful in screening for trisomy 21.
确定妊娠11 - 14周时测量胎儿耳长在染色体缺陷筛查中的价值。
在妊娠11 - 14周进行绒毛取样进行核型分析前，对450例胎儿立即测量其耳长。
中位孕周为12（范围11 - 14）周。所有病例均成功检测到胎儿耳部。409例胎儿核型正常，41例异常，其中21 -三体综合征32例。在染色体正常组中，胎儿耳长随顶臀长显著增加，从顶臀长45 mm时的平均3.�mm增加到84 mm时的6.9 mm。在21 -三体综合征胎儿中，耳长中位数比相同顶臀长的正常均值显著低0.45 mm（P = 0.013），但仅2例（6.3%）低于正常范围的第5百分位数。在染色体正常胎儿（r = - 0.015，P = 0.753）或21 -三体综合征胎儿（r = - 0.014，P = 0.94）中，耳长差值与颈部半透明层厚度差值之间均无显著相关性。
妊娠11 - 14周时，21 -三体综合征胎儿的耳长显著缩短，但与正常的偏差程度过小，该测量方法对21 -三体综合征筛查无实用价值。
