Takeno Atsushi, Fujitani Kazumasa, Tsujinaka Toshimasa, Hirao Motohiro, Takeda Yutaka, Kashiwazaki Masaki, Mishima Hideyuki, Ikenaga Masakazu, Sawamura Toshiro, Hasuike Yasunori
Dept. of Surgery, Osaka National Hospital.
Gan To Kagaku Ryoho. 2003 Oct;30(11):1631-4.
We evaluated the effectiveness of arterial infusion chemotherapy for liver metastasis from gastric cancer. Nineteen patients (9 synchronous cases, 10 metachronous cases) were treated with hepatic arterial infusion chemotherapy (HAIC). The response rate was 26% (CR 3, PR 2, PD 14), and the median survival time was 357 days after the diagnosis of liver metastasis. The treatment was discontinued in 8 patients because of treatment associated complications and disease progression. Absence of extrahepatic lesion, response of HAIC, and hepatectomy did not improve the prognosis. The combination of systemic chemotherapy with HAIC tended to improve the prognosis. It may be necessary to reevaluate HAIC as a treatment modality for liver metastasis from gastric cancer.
我们评估了动脉灌注化疗对胃癌肝转移的疗效。19例患者（9例同时性转移，10例异时性转移）接受了肝动脉灌注化疗（HAIC）。缓解率为26%（完全缓解3例，部分缓解2例，疾病进展14例），肝转移诊断后的中位生存时间为357天。8例患者因治疗相关并发症和疾病进展而停止治疗。无肝外病变、HAIC反应及肝切除术并未改善预后。全身化疗联合HAIC有改善预后的趋势。可能有必要重新评估HAIC作为胃癌肝转移的一种治疗方式。
