Ou Haodi, Li Xiaodong, Chang Shulin, Li Guijie, Chen Feng, Jiang Song
Department of Radiology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Medicine and Health Key Laboratory of Abdominal Medicine Imaging, Jinan, China.
Graduate school, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.
Front Oncol. 2025 Jun 5;15:1544061. doi: 10.3389/fonc.2025.1544061. eCollection 2025.
Hepatic arterial infusion chemotherapy (HAIC) is one of the local treatment modalities employed for liver metastases. HAIC targets the delivery of chemotherapy drugs to the affected area by inserting a catheter into the tumor's blood-supplying artery. This approach not only enhances drug concentration within the tumor site, but also significantly reduces systemic side effects. Currently, there are various chemotherapeutic regimens available for HAIC in liver metastases; however, determining the optimal therapeutic agent remains elusive. This article provides a comprehensive review of HAIC dosing regimens and multimodal therapy for liver metastases originating from colorectal, breast, and gastric cancers. Meanwhile, this paper briefly outlines ongoing research on HAIC treatment for liver metastases associated with esophageal cancer, gastroenteropancreatic neuroendocrine tumors, and uveal melanoma.
肝动脉灌注化疗（HAIC）是用于肝转移瘤的局部治疗方式之一。HAIC通过将导管插入肿瘤供血动脉，将化疗药物输送至受累区域。这种方法不仅能提高肿瘤部位的药物浓度，还能显著降低全身副作用。目前，有多种化疗方案可用于肝转移瘤的HAIC治疗；然而，确定最佳治疗药物仍很困难。本文全面综述了HAIC给药方案以及用于治疗源自结直肠癌、乳腺癌和胃癌的肝转移瘤的多模式疗法。同时，本文简要概述了HAIC治疗与食管癌、胃肠胰神经内分泌肿瘤和葡萄膜黑色素瘤相关的肝转移瘤的正在进行的研究。
