Gong NanLing, Chatterjee Subroto
Johns Hopkins Singapore-National Heart Centre Vascular Biology Program, Singapore.
Mol Cell Biochem. 2003 Nov;253(1-2):151-8. doi: 10.1023/a:1026016628386.
Platelet endothelial cell adhesion molecule (PECAM-1) is a member of the superfamily of immunoglobulins. This cell adhesion molecule has been implicated to mediate the adhesion and trans-endothelial migration of T lymphocytes/monocytes into the vascular wall, a critical step in the initiation of atherogenesis. Current thinking, however, posits that PECAM-1 by virtue of being a scaffolding molecule may well play a role in several signal transduction reactions. As a consequence, this cell adhesion molecule may be responsible for several biological and pathophysiological functions such as thrombosis, and inflammation. Evidence has also been put forward for a potential role of PECAM-1 in apoptosis and atherosclerosis. This article focuses on the structure of PECAM-1 and its role in intracellular signaling and implications in health and disease.
血小板内皮细胞黏附分子（PECAM-1）是免疫球蛋白超家族的成员。这种细胞黏附分子被认为可介导T淋巴细胞/单核细胞黏附并跨内皮迁移至血管壁，这是动脉粥样硬化发生起始阶段的关键步骤。然而，目前的观点认为，PECAM-1作为一种支架分子，很可能在多种信号转导反应中发挥作用。因此，这种细胞黏附分子可能与多种生物学和病理生理功能有关，如血栓形成和炎症。也有证据表明PECAM-1在细胞凋亡和动脉粥样硬化中具有潜在作用。本文重点介绍PECAM-1的结构及其在细胞内信号传导中的作用，以及对健康和疾病的影响。
