Kinnamon K E, Engle R R, Poon B T, McCall J W, Dzimianski M T
School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799, USA.
Mil Med. 1994 May;159(5):368-72.
Parasitic nematode worms which produce filariasis in humans place approximately one billion people at risk in more than 75 countries. More than 100 million people are infected with these diseases and are recognized as being of significant military importance. During World War II, filariasis was among the leading causes of medical evacuation from the entire South Pacific area. Agents available to treat the diseases exhibit significant toxicity. Better drugs are urgently needed. Data are reported from work using a Mongolian jird animal model on a new class of potential drugs, thiosemicarbazones. These compounds exhibit activity against the parasites which cause both lymphatic filariasis and the "onchocerciasis type" of the disease.
能在人类中引发丝虫病的寄生线虫使超过75个国家的约10亿人面临风险。超过1亿人感染了这些疾病，并且这些疾病被认为具有重大军事意义。在第二次世界大战期间，丝虫病是整个南太平洋地区医疗后送的主要原因之一。现有的治疗这些疾病的药物具有显著毒性。迫切需要更好的药物。本文报道了在蒙古沙鼠动物模型上对一类新型潜在药物——硫代氨基脲进行研究所得的数据。这些化合物对引发淋巴丝虫病和“盘尾丝虫病型”疾病的寄生虫具有活性。
