Stabellini G, Calastrini C, Gagliano N, Dellavia C, Moscheni C, Vizzotto L, Occhionorelli S, Gioia M
Department of Human Anatomy-Lita di Segrate, University of Milan, Italy.
Int J Clin Pharmacol Res. 2003;23(1):17-22.
Serum and erythrocyte levels of the polyamines spermine, spermidine and putrescine, as well as ornithine decarboxylase in erythrocytes, were studied in patients with different neoplasms (breast, lung and colon cancer) and in those with a nonmalignant proliferative disease (familial polyposis). The blood levels of polyamines and the spermine/putrescine ratio were significantly higher in all tumors and in nonmalignant colon polyposis. In erythrocyte ornithine decarboxylase activity, spermine and spermidine levels, as well as spermidine/putrescine and spermine/putrescine ratios showed a significant decrease after surgery and chemotherapy. Our data suggest that high levels of blood polyamines and erythrocyte ornithine decarboxylase activity are related to cell proliferation and cancer treatment, but that levels of polyamines in serum and erythrocytes are still significantly high after cancer treatment and are similar to those in polyposis disease. Polyamines are related to nuclear activity during differentiation; therefore, the altered turnover of polyamines could be a sign of abnormal nuclear function. Since polyamines stimulate protooncogene expression, their high levels could be considered an important cofactor in malignant cell transformation.
对患有不同肿瘤（乳腺癌、肺癌和结肠癌）的患者以及患有非恶性增殖性疾病（家族性息肉病）的患者，研究了血清和红细胞中的多胺（精胺、亚精胺和腐胺）水平，以及红细胞中的鸟氨酸脱羧酶。在所有肿瘤和非恶性结肠息肉病中，多胺的血液水平以及精胺/腐胺比值均显著升高。手术后和化疗后，红细胞鸟氨酸脱羧酶活性、精胺和亚精胺水平以及亚精胺/腐胺和精胺/腐胺比值均显著下降。我们的数据表明，血液中多胺的高水平和红细胞鸟氨酸脱羧酶活性与细胞增殖和癌症治疗有关，但癌症治疗后血清和红细胞中的多胺水平仍然显著升高，且与息肉病患者的水平相似。多胺与分化过程中的核活性有关；因此，多胺代谢的改变可能是核功能异常的一个标志。由于多胺刺激原癌基因表达，其高水平可被视为恶性细胞转化的一个重要辅助因子。
