Lee Soo Joo, Cho Soo-Jin, Moon Heui-Soo, Shon Young-Min, Lee Kwang Ho, Kim Dong-Ik, Lee Byung-Boong, Byun Hong Sik, Han Seol-Heui, Chung Chin-Sang
Departments of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Arch Neurol. 2003 Nov;60(11):1561-4. doi: 10.1001/archneur.60.11.1561.
To evaluate the frequency of intracranial atherosclerosis among patients with steno-occlusive extracranial carotid artery disease and to determine if there are factors related to the combined intracranial atherosclerosis.
Cross-sectional study.
A tertiary referral hospital. Patients We studied 142 consecutive patients who had atherosclerotic steno-occlusive lesions (defined as > or =30% narrowing of the luminal diameter or occlusion) of an extracranial carotid artery confirmed by conventional angiography. We excluded patients who had potential cardiogenic sources of embolism. Potential vascular risk factors for each patient were obtained from medical records. Main Outcome Measure We determined the location and severity of atherosclerotic lesions by conventional angiography. We compared the vascular risk factors between patients with steno-occlusive extracranial carotid artery disease alone and patients with combined intracranial atherosclerosis and extracranial carotid artery disease.
Intracranial steno-occlusive lesions (> or =30% stenosis or occlusion) were found in 80 patients (56.3%). Of 121 patients with significant (> or =50% stenosis or occlusion) extracranial carotid artery disease, 58 (47.9%) also had significant lesions of intracranial arteries. Univariate and multivariate analyses showed that diabetes mellitus was the only significant factor associated with combined intracranial atherosclerosis in patients with extracranial carotid artery disease.
Intracranial atherosclerosis is common in Korean patients with steno-occlusive extracranial carotid artery disease. Diabetes mellitus is associated with intracranial atherosclerosis in patients who had steno-occlusive extracranial carotid artery disease.
评估颅外颈动脉狭窄闭塞性疾病患者颅内动脉粥样硬化的发生率，并确定是否存在与合并颅内动脉粥样硬化相关的因素。
横断面研究。
一家三级转诊医院。患者我们研究了142例经传统血管造影证实患有颅外颈动脉粥样硬化狭窄闭塞性病变（定义为管腔直径狭窄≥30%或闭塞）的连续患者。我们排除了具有潜在心源性栓塞源的患者。从病历中获取每位患者的潜在血管危险因素。主要观察指标通过传统血管造影确定动脉粥样硬化病变的位置和严重程度。我们比较了单纯颅外颈动脉狭窄闭塞性疾病患者与合并颅内动脉粥样硬化和颅外颈动脉疾病患者之间的血管危险因素。
80例患者（56.3%）发现颅内狭窄闭塞性病变（狭窄或闭塞≥30%）。在121例患有严重（狭窄或闭塞≥50%）颅外颈动脉疾病的患者中，58例（47.9%）颅内动脉也有严重病变。单因素和多因素分析表明，糖尿病是颅外颈动脉疾病患者合并颅内动脉粥样硬化的唯一显著相关因素。
颅内动脉粥样硬化在韩国颅外颈动脉狭窄闭塞性疾病患者中很常见。糖尿病与颅外颈动脉狭窄闭塞性疾病患者的颅内动脉粥样硬化有关。
