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形态发生素音猬因子与netrin-1协同作用，引导脊髓中的轴突。

The morphogen sonic hedgehog collaborates with netrin-1 to guide axons in the spinal cord.

作者信息

Salinas Patricia C

机构信息

Department of Biological Sciences, Imperial College London, Exhibition Road, SW7 2AZ, London, UK.

出版信息

Trends Neurosci. 2003 Dec;26(12):641-3. doi: 10.1016/j.tins.2003.09.006.

DOI:10.1016/j.tins.2003.09.006
PMID:14624844
Abstract

Netrin-1 is an attractive axon guidance molecule required for the proper navigation of commissural axons to the floor plate in the spinal cord. A new study now shows that sonic hedgehog (Shh) from midline structures collaborates with netrin-1 to guide commissural axons. This new role for the morphogen Shh raises the possibility that principles similar to those used to establish positional information in embryonic patterning are also employed during axon navigation.

摘要

Netrin-1是一种具有吸引力的轴突导向分子，是脊髓中连合轴突正确导航至底板所必需的。一项新研究表明，来自中线结构的音猬因子（Shh）与Netrin-1协同作用以引导连合轴突。形态发生素Shh的这一新作用增加了一种可能性，即类似于在胚胎模式形成中用于建立位置信息的原理也在轴突导航过程中被采用。

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1
The morphogen sonic hedgehog collaborates with netrin-1 to guide axons in the spinal cord.形态发生素音猬因子与netrin-1协同作用，引导脊髓中的轴突。
Trends Neurosci. 2003 Dec;26(12):641-3. doi: 10.1016/j.tins.2003.09.006.
2
The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance.形态发生素音猬因子是一种轴突化学引诱剂，它在中线轴突导向中与网蛋白-1协同作用。
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3
Integration of shallow gradients of Shh and Netrin-1 guides commissural axons.Shh 和 Netrin-1 的浅层梯度整合指导连合轴突。
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Sonic hedgehog guides commissural axons along the longitudinal axis of the spinal cord.音猬因子沿脊髓纵轴引导连合轴突。
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[Guidance of commissural axons in the neural tube--related to the induction and differentiation of ventral neurons].[神经管中连合轴突的导向——与腹侧神经元的诱导和分化相关]
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Axon guidance by diffusible chemoattractants: a gradient of netrin protein in the developing spinal cord.可扩散化学引诱剂介导的轴突导向：发育中的脊髓中netrin蛋白的梯度分布
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Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord.Netrin蛋白是胚胎脊髓中连合轴突的可扩散化学趋向性因子。
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Long-Range Guidance of Spinal Commissural Axons by Netrin1 and Sonic Hedgehog from Midline Floor Plate Cells.脊髓连合轴突由中线基板细胞分泌的 Netrin1 和 Sonic Hedgehog 进行远程导向。
Neuron. 2019 Feb 20;101(4):635-647.e4. doi: 10.1016/j.neuron.2018.12.025. Epub 2019 Jan 17.

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