Lu Dengfeng, Feng Yun, Liu Guangjie, Yang Yayi, Ren Yubo, Chen Zhouqing, Sun Xiaoou, Guan Yixiang, Wang Zhong
Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Suzhou Medical College of Soochow University, Suzhou, Jiangsu, China.
Front Neurosci. 2023 Oct 12;17:1268883. doi: 10.3389/fnins.2023.1268883. eCollection 2023.
Ensuring mitochondrial quality is essential for maintaining neuronal homeostasis, and mitochondrial transport plays a vital role in mitochondrial quality control. In this review, we first provide an overview of neuronal mitochondrial transport, followed by a detailed description of the various motors and adaptors associated with the anterograde and retrograde transport of mitochondria. Subsequently, we review the modest evidence involving mitochondrial transport mechanisms that has surfaced in acute neurological disorders, including traumatic brain injury, spinal cord injury, spontaneous intracerebral hemorrhage, and ischemic stroke. An in-depth study of this area will help deepen our understanding of the mechanisms underlying the development of various acute neurological disorders and ultimately improve therapeutic options.
确保线粒体质量对于维持神经元内环境稳定至关重要，而线粒体运输在线粒体质量控制中发挥着关键作用。在本综述中，我们首先概述神经元线粒体运输，随后详细描述与线粒体顺行和逆行运输相关的各种动力蛋白和衔接蛋白。接着，我们回顾在急性神经疾病中出现的有关线粒体运输机制的适度证据，这些疾病包括创伤性脑损伤、脊髓损伤、自发性脑出血和缺血性中风。对该领域的深入研究将有助于加深我们对各种急性神经疾病发病机制的理解，并最终改善治疗选择。
