Whittington Miles A, Traub Roger D
School of Biomedical Sciences, University of Leeds, LS2 9NQ, Leeds, UK.
Trends Neurosci. 2003 Dec;26(12):676-82. doi: 10.1016/j.tins.2003.09.016.
In vitro models of rhythms of cognitive relevance, such as gamma (30-80 Hz) and theta (5-12 Hz) rhythms in the hippocampus, demonstrate an absolute requirement for phasic inhibitory synaptic transmission. Such rhythms can occur transiently, of approximately 1 s duration, or persistently, lasting for many hours. In the latter case, stable patterns of interneuron output, and their postsynaptic consequences for pyramidal cell membrane potential, occur despite known constraints of synaptic habituation and potentiation. This review concentrates on recent in vitro evidence revealing a division of labour among different subclasses of interneurons with respect to the frequency of persistent rhythms, and the crucial dependence on gap-junction-mediated intercellular communication for the generation and maintenance of these rhythms.
与认知相关的节律的体外模型，如海马体中的γ（30 - 80赫兹）和θ（5 - 12赫兹）节律，表明相位性抑制性突触传递是绝对必需的。这种节律可以短暂出现，持续时间约为1秒，也可以持续存在，持续数小时。在后一种情况下，尽管存在突触习惯化和增强的已知限制，但中间神经元输出的稳定模式及其对锥体细胞膜电位的突触后影响仍然会出现。本综述集中于最近的体外证据，这些证据揭示了不同亚类中间神经元在持续节律频率方面的分工，以及间隙连接介导的细胞间通讯对这些节律的产生和维持的关键依赖性。
