COX-3：小鼠神经组织和细胞中环氧化酶-1的一种剪接变体。

COX-3: a splice variant of cyclooxygenase-1 in mouse neural tissue and cells.

作者信息

Shaftel Solomon S, Olschowka John A, Hurley Sean D, Moore Amy H, O'Banion M Kerry

机构信息

Department of Neurobiology and Anatomy, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.

出版信息

Brain Res Mol Brain Res. 2003 Nov 26;119(2):213-5. doi: 10.1016/j.molbrainres.2003.09.006.

DOI:10.1016/j.molbrainres.2003.09.006

PMID:14625089

Abstract

We have detected an expressed mRNA encoding a splice variant of COX-1 in the mouse central nervous system. This isoform, referred to as COX-3, is identical in sequence to COX-1 except for the in-frame retention of intron 1. Like its counterpart COX-1, COX-3 does not generally appear to be induced by acute inflammatory stimulation.

摘要

我们在小鼠中枢神经系统中检测到一种表达的mRNA，其编码环氧化酶-1（COX-1）的一种剪接变体。这种同工型被称为COX-3，除了1号内含子在可读框内保留外，其序列与COX-1相同。与它的对应物COX-1一样，COX-3一般似乎不会被急性炎症刺激所诱导。