Bendel Catherine M
Division of Neonatology, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, USA.
Semin Perinatol. 2003 Oct;27(5):357-64. doi: 10.1016/s0146-0005(03)00059-4.
Candida species are important nosocomial pathogens in the newborn population, particularly among the premature very-low-birth-weight infants in neonatal intensive care units. Candida colonization of the neonatal skin and gastrointestinal tract is an important first step in the pathogenesis of invasive disease. C albicans is the most commonly isolated species in colonized or infected infants. Over the past decade the incidence of both colonization and infection with other Candida species, particularly C parapsilosis, has risen dramatically. Colonization of the infant occurs early in life and is affected by a variety of common practices in neonatal intensive care. Microbial factors also augment colonization, including the ability of Candida to adhere to human epithelium. A better understanding of the complex interactions between host risk factors and virulence traits of colonizing yeast may allow the risk of systemic spread to be reduced in the population of premature infants.
念珠菌属是新生儿群体中重要的医院感染病原体，尤其是在新生儿重症监护病房中的早产极低体重儿中。新生儿皮肤和胃肠道的念珠菌定植是侵袭性疾病发病机制中的重要第一步。白色念珠菌是定植或感染婴儿中最常分离出的菌种。在过去十年中，其他念珠菌属，特别是近平滑念珠菌的定植和感染发生率急剧上升。婴儿的定植在生命早期就会发生，并受到新生儿重症监护中各种常见操作的影响。微生物因素也会增加定植，包括念珠菌粘附于人体上皮的能力。更好地理解宿主风险因素与定植酵母毒力特征之间的复杂相互作用，可能会降低早产儿群体中系统性传播的风险。
