通过三氟甲磺酸钪催化苄基丙二酸亚异丙酯衍生物的分子内傅克酰基化反应便捷合成多取代的1-茚酮
Convenient access to polysubstituted 1-indanones by Sc(OTf)3-catalyzed intramolecular Friedel-Crafts acylation of benzyl Meldrum's acid derivatives.
作者信息
Fillion Eric, Fishlock Dan
机构信息
Department of Chemistry, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada.
出版信息
Org Lett. 2003 Nov 27;5(24):4653-6. doi: 10.1021/ol035817m.
PMID:14627407
Abstract
[reaction: see text] The intramolecular Friedel-Crafts acylation of benzyl Meldrum's acids is catalyzed by Sc(OTf)(3) under mild reaction conditions. Several polysubstituted 1-indanones have been prepared.
摘要
[反应：见正文] 在温和的反应条件下，苄基丙二酸亚异丙酯的分子内傅克酰基化反应由三氟甲磺酸钪催化。已制备出几种多取代的1-茚酮。
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