多巴胺和章鱼胺可区分果蝇中厌恶和偏好性嗅觉记忆。
Dopamine and octopamine differentiate between aversive and appetitive olfactory memories in Drosophila.
作者信息
Schwaerzel Martin, Monastirioti Maria, Scholz Henrike, Friggi-Grelin Florence, Birman Serge, Heisenberg Martin
机构信息
Lehrstuhl für Genetik und Neurobiologie, Biozentrum, Am Hubland, D-97074 Würzburg, Germany.
出版信息
J Neurosci. 2003 Nov 19;23(33):10495-502. doi: 10.1523/JNEUROSCI.23-33-10495.2003.
Abstract
The catecholamines play a major role in the regulation of behavior. Here we investigate, in the fly Drosophila melanogaster, the role of dopamine and octopamine (the presumed arthropod homolog of norepinephrine) during the formation of appetitive and aversive olfactory memories. We find that for the formation of both types of memories, cAMP signaling is necessary and sufficient within the same subpopulation of mushroom-body intrinsic neurons. On the other hand, memory formation can be distinguished by the requirement for different catecholamines, dopamine for aversive and octopamine for appetitive conditioning. Our results suggest that in associative conditioning, different memories are formed of the same odor under different circumstances, and that they are linked to the respective motivational systems by their specific modulatory pathways.
摘要
儿茶酚胺在行为调节中起主要作用。在此，我们以果蝇为研究对象，探究多巴胺和章鱼胺（推测为节肢动物体内去甲肾上腺素的同源物）在形成嗅觉偏好性和厌恶性记忆过程中的作用。我们发现，对于这两种类型记忆的形成，cAMP信号传导在蘑菇体固有神经元的同一亚群中是必要且充分的。另一方面，记忆形成可通过对不同儿茶酚胺的需求来区分，厌恶性记忆形成需要多巴胺，而偏好性条件反射需要章鱼胺。我们的研究结果表明，在联想性条件反射中，相同的气味在不同情况下会形成不同的记忆，并且它们通过各自特定的调节途径与相应的动机系统相联系。
相似文献
1
Dopamine and octopamine differentiate between aversive and appetitive olfactory memories in Drosophila.多巴胺和章鱼胺可区分果蝇中厌恶和偏好性嗅觉记忆。
J Neurosci. 2003 Nov 19;23(33):10495-502. doi: 10.1523/JNEUROSCI.23-33-10495.2003.
2
Concerted Actions of Octopamine and Dopamine Receptors Drive Olfactory Learning.章鱼胺和多巴胺受体的协同作用驱动嗅觉学习。
J Neurosci. 2020 May 20;40(21):4240-4250. doi: 10.1523/JNEUROSCI.1756-19.2020. Epub 2020 Apr 10.
3
Shared mushroom body circuits underlie visual and olfactory memories in Drosophila.共享的蘑菇体回路是果蝇视觉和嗅觉记忆的基础。
Elife. 2014 Aug 19;3:e02395. doi: 10.7554/eLife.02395.
4
Cyclic AMP-dependent plasticity underlies rapid changes in odor coding associated with reward learning.环腺苷酸依赖的可塑性是与奖励学习相关的气味编码快速变化的基础。
Proc Natl Acad Sci U S A. 2018 Jan 16;115(3):E448-E457. doi: 10.1073/pnas.1709037115. Epub 2017 Dec 28.
5
The role of dopamine in Drosophila larval classical olfactory conditioning.多巴胺在果蝇幼虫经典嗅觉条件反射中的作用。
PLoS One. 2009 Jun 12;4(6):e5897. doi: 10.1371/journal.pone.0005897.
6
Punishment prediction by dopaminergic neurons in Drosophila.果蝇中多巴胺能神经元对惩罚的预测
Curr Biol. 2005 Nov 8;15(21):1953-60. doi: 10.1016/j.cub.2005.09.042.
7
Participation of octopaminergic reward system and dopaminergic punishment system in insect olfactory learning revealed by pharmacological study.药理学研究揭示章鱼胺能奖赏系统和多巴胺能惩罚系统在昆虫嗅觉学习中的作用。
Eur J Neurosci. 2005 Sep;22(6):1409-16. doi: 10.1111/j.1460-9568.2005.04318.x.
8
Reinforcement signalling in Drosophila; dopamine does it all after all.果蝇中的强化信号；多巴胺毕竟无所不能。
Curr Opin Neurobiol. 2013 Jun;23(3):324-9. doi: 10.1016/j.conb.2013.01.005. Epub 2013 Feb 5.
9
Genetic Dissection of Aversive Associative Olfactory Learning and Memory in Drosophila Larvae.果蝇幼虫厌恶联想性嗅觉学习与记忆的遗传学剖析
PLoS Genet. 2016 Oct 21;12(10):e1006378. doi: 10.1371/journal.pgen.1006378. eCollection 2016 Oct.
10
Dopaminergic modulation of cAMP drives nonlinear plasticity across the Drosophila mushroom body lobes.多巴胺对环磷酸腺苷（cAMP）的调节驱动果蝇蘑菇体叶中的非线性可塑性。
Curr Biol. 2014 Apr 14;24(8):822-31. doi: 10.1016/j.cub.2014.03.021. Epub 2014 Mar 27.
引用本文的文献
1
A pair of dopaminergic neurons DAN-c1 mediate larval aversive olfactory learning through D2-like receptors.一对多巴胺能神经元DAN-c1通过D2样受体介导幼虫厌恶嗅觉学习。
Elife. 2025 Aug 13;13:RP100890. doi: 10.7554/eLife.100890.
2
as a neurobehavioral model for sex differences in stress response.作为应激反应中性别差异的神经行为模型。
Front Behav Neurosci. 2025 Jul 11;19:1581763. doi: 10.3389/fnbeh.2025.1581763. eCollection 2025.
3
Avoidance engages dopaminergic punishment in .回避行为会引发多巴胺能惩罚作用。 （你提供的原文似乎不完整，这里是根据现有内容尽量完善后的翻译，如有偏差请根据完整原文调整）
bioRxiv. 2025 Jul 10:2025.07.07.663268. doi: 10.1101/2025.07.07.663268.
4
A neuromorphic model of active vision shows how spatiotemporal encoding in lobula neurons can aid pattern recognition in bees.一种主动视觉的神经形态模型展示了小叶神经元中的时空编码如何帮助蜜蜂进行模式识别。
Elife. 2025 Jul 1;14:e89929. doi: 10.7554/eLife.89929.
5
What could evolve in the evolution of memory?在记忆的进化过程中会发生什么演变？
Philos Trans R Soc Lond B Biol Sci. 2025 Jun 26;380(1929):20240109. doi: 10.1098/rstb.2024.0109.
6
Connectomic analysis of taste circuits in Drosophila.果蝇味觉回路的连接组学分析
Sci Rep. 2025 Feb 12;15(1):5278. doi: 10.1038/s41598-025-89088-9.
7
Long-term social memory of mate copying in Drosophila melanogaster is localized in mushroom bodies.黑腹果蝇中配偶复制行为的长期社会记忆定位于蕈形体。
Sci Rep. 2025 Feb 12;15(1):5262. doi: 10.1038/s41598-025-88535-x.
8
Driver lines for studying associative learning in .用于研究……中联想学习的驱动系。 （原文句末不完整，以上为根据现有内容翻译）
Elife. 2025 Jan 29;13:RP94168. doi: 10.7554/eLife.94168.
9
Dopamine neurons that inform Drosophila olfactory memory have distinct, acute functions driving attraction and aversion.向果蝇嗅觉记忆提供信息的多巴胺神经元具有驱动吸引和厌恶的独特急性功能。
PLoS Biol. 2024 Nov 18;22(11):e3002843. doi: 10.1371/journal.pbio.3002843. eCollection 2024 Nov.
10
The Neural Correlations of Olfactory Associative Reward Memories in .在. 中嗅觉联想奖励记忆的神经相关性。
Cells. 2024 Oct 17;13(20):1716. doi: 10.3390/cells13201716.
本文引用的文献
1
Effect of pheromones, hormones, and handling on sucrose response thresholds of honey bees (Apis mellifera L.).信息素、激素及处理方式对蜜蜂（西方蜜蜂）蔗糖反应阈值的影响
J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2003 Sep;189(9):675-84. doi: 10.1007/s00359-003-0442-y. Epub 2003 Aug 7.
2
Expression of a D1 dopamine receptor dDA1/DmDOP1 in the central nervous system of Drosophila melanogaster.一种D1多巴胺受体dDA1/DmDOP1在黑腹果蝇中枢神经系统中的表达。
Gene Expr Patterns. 2003 May;3(2):237-45. doi: 10.1016/s1567-133x(02)00098-4.
3
Mushroom body memoir: from maps to models.蘑菇体记忆：从图谱到模型
Nat Rev Neurosci. 2003 Apr;4(4):266-75. doi: 10.1038/nrn1074.
4
Targeted gene expression in Drosophila dopaminergic cells using regulatory sequences from tyrosine hydroxylase.利用酪氨酸羟化酶的调控序列在果蝇多巴胺能细胞中进行靶向基因表达。
J Neurobiol. 2003 Mar;54(4):618-27. doi: 10.1002/neu.10185.
5
Activity-dependent presynaptic facilitation and hebbian LTP are both required and interact during classical conditioning in Aplysia.在海兔的经典条件反射过程中，依赖活动的突触前易化和赫布型长时程增强都是必需的，且二者相互作用。
Neuron. 2003 Jan 9;37(1):135-47. doi: 10.1016/s0896-6273(02)01129-7.
6
Experimental evolution of learning ability in fruit flies.果蝇学习能力的实验性进化
Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14274-9. doi: 10.1073/pnas.222371199. Epub 2002 Oct 21.
7
Extinction antagonizes olfactory memory at the subcellular level.消退在亚细胞水平上拮抗嗅觉记忆。
Neuron. 2002 Aug 29;35(5):951-60. doi: 10.1016/s0896-6273(02)00832-2.
8
Octopamine modulates responsiveness to foraging-related stimuli in honey bees (Apis mellifera).章鱼胺调节蜜蜂（西方蜜蜂）对觅食相关刺激的反应。
J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2002 Sep;188(8):603-10. doi: 10.1007/s00359-002-0335-5. Epub 2002 Sep 7.
9
A trace amine, tyramine, functions as a neuromodulator in Drosophila melanogaster.一种痕量胺，即酪胺，在黑腹果蝇中作为神经调质发挥作用。
Neurosci Lett. 2002 Sep 6;329(3):324-8. doi: 10.1016/s0304-3940(02)00596-7.
10
Synaptic organization of the mushroom body calyx in Drosophila melanogaster.黑腹果蝇中蕈形体花萼的突触组织
J Comp Neurol. 2002 Apr 8;445(3):211-26. doi: 10.1002/cne.10155.
Zotero 插件