Dray A, Patel I A, Perkins M N, Rueff A, Urban L
Sandoz Institute for Medical Research, London, UK.
Agents Actions Suppl. 1992;38 ( Pt 2):93-7.
Bradykinin-induced activation of peripheral nociceptors has been studied in an isolated spinal cord/tail preparation from the neonatal rat. Prolonged administration of bradykinin consistently produced a selective desensitization which could be prevented by concanavalin A but not by succinyl concanavalin A or phenylarsine oxide. These data indicate that mannose-containing glycoproteins occur in or close to the bradykinin receptor site. In addition the desensitization observed under the present conditions, did not involve the internalization of bradykinin receptors.
缓激肽诱导的外周伤害感受器激活已在新生大鼠的离体脊髓/尾巴制备物中进行了研究。缓激肽的长期给药始终产生选择性脱敏，伴刀豆球蛋白A可预防这种脱敏，但琥珀酰伴刀豆球蛋白A或氧化苯砷则不能。这些数据表明，含甘露糖的糖蛋白存在于缓激肽受体位点或其附近。此外，在当前条件下观察到的脱敏不涉及缓激肽受体的内化。
