缓激肽与去甲肾上腺素在体外正常及炎症状态下对大鼠皮肤伤害感受器的相互作用。

Interactions of bradykinin and norepinephrine on rat cutaneous nociceptors in both normal and inflamed conditions in vitro.

作者信息

Banik Ratan Kumar, Sato Jun, Giron Rocio, Yajima Hiroki, Mizumura Kazue

机构信息

Department of Neural Regulation, Research Institute of Environmental Medicine, Nagoya University, Furo, Chikusa, Nagoya 464-8601, Japan.

出版信息

Neurosci Res. 2004 Aug;49(4):421-5. doi: 10.1016/j.neures.2004.05.002.

DOI:10.1016/j.neures.2004.05.002

PMID:15236868

Abstract

Many inflammatory chemical mediators excite or sensitize nociceptors, which had led some researchers to believe that they may interact with each other to maintain a persistent painful state. We examined how the excitatory mediators norepinephrine (NE) and bradykinin (BK) interact, using single fiber recordings from cutaneous nociceptors. We observed that NE augmented the BK-induced response in both control and adjuvant-inflamed rats in a way different from NE-induced excitation in inflamed animals only. BK also tended to augment the NE-induced response (examined only in inflamed rats). Our results provide the first evidence that BK and NE synergistically interact on nociceptors.

摘要

许多炎症化学介质会刺激伤害感受器或使其敏感化，这使得一些研究人员认为它们可能相互作用以维持持续的疼痛状态。我们使用皮肤伤害感受器的单纤维记录，研究了兴奋性介质去甲肾上腺素（NE）和缓激肽（BK）如何相互作用。我们观察到，在对照大鼠和佐剂诱导炎症的大鼠中，NE均以一种不同于仅在炎症动物中NE诱导兴奋的方式增强了BK诱导的反应。BK也倾向于增强NE诱导的反应（仅在炎症大鼠中进行了检测）。我们的结果首次证明了BK和NE在伤害感受器上存在协同相互作用。