Hua Li-Xin, Wu Hong-Fei, Sui Yuan-Geng, Chen Shuang-Guan, Xu Zheng-Quan, Zhang Wei, Qian Li-Xin
Department of Urology, First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu 210029, China.
Zhonghua Nan Ke Xue. 2003 Oct;9(7):510-1.
To evaluate the clinical efficacy of alpha-1 A adrenoceptor antagonist (tamsulosin) in the treatment of benign prostatic hyperplasia (BPH) patients with acute urinary retention.
Seventy-two BPH patients with acute retention of urine were randomly divided into treatment group and control group of 36 patients each. All the patients were treated with indwelling catheter, oral antibiotics and the patients in treatment group tamsulosin 0.4 mg once a day for 3 days. The catheter was removed after 72 hours of treatment.
After removal of the catheter, 44% (32/72) of patients voided successfully. The effect rates were 61% (22/36) in the tamsulosin treatment group and 28% (10/36) in the control group(P < 0.01).
Treatment with tamsulosin was effective in raising the success rate of voiding without catheter after an episode of acute urinary retention. The efficacy of treatment was not influenced by the volume of prostate.
评估α-1A肾上腺素能受体拮抗剂（坦索罗辛）治疗良性前列腺增生（BPH）合并急性尿潴留患者的临床疗效。
72例BPH合并急性尿潴留患者随机分为治疗组和对照组，每组36例。所有患者均留置导尿管并口服抗生素，治疗组患者加用坦索罗辛0.4mg，每日1次，连用3天。治疗72小时后拔除导尿管。
拔除导尿管后，44%（32/72）的患者成功排尿。坦索罗辛治疗组有效率为61%（22/36），对照组为28%（10/36）（P<0.01）。
坦索罗辛治疗可有效提高急性尿潴留发作后无导尿管排尿成功率。治疗效果不受前列腺体积影响。
