Holder I A, Neely A N
Department of Surgery, University of Cincinnati College of Medicine, Ohio.
Agents Actions Suppl. 1992;38 ( Pt 3):329-42.
Trauma causes increases in total protease load in the circulation of the traumatized host animal or patient. This increase is due, in part, to Hageman Factor activation followed by down-line cascade system activation. Concomitant with the activation of these systems is a reduced host capacity to resist infection. Infection superimposed on a traumatized host increases the total host protease load even more by additional activation of Hageman Factor and cascade systems.
创伤会导致受创伤的宿主动物或患者循环系统中的总蛋白酶负荷增加。这种增加部分归因于凝血因子激活，随后是下游级联系统激活。与这些系统激活相伴的是宿主抗感染能力的降低。叠加在受创伤宿主上的感染会通过进一步激活凝血因子和级联系统，使宿主的总蛋白酶负荷进一步增加。
