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缓激肽拮抗剂Hoe 140可抑制角叉菜胶和热诱导的大鼠爪部水肿。

The bradykinin antagonist Hoe 140 inhibits carrageenan- and thermically induced paw oedema in rats.

作者信息

Wirth K J, Alpermann H G, Satoh R, Inazu M

机构信息

Hoechst AG, Frankfurt, FRG.

出版信息

Agents Actions Suppl. 1992;38 ( Pt 3):428-31.

PMID:1462876
Abstract

The new and highly potent B2 bradykinin (BK) antagonist Hoe 140 was tested for its ability to inhibit oedema of rat paws induced by scalding and carrageenan. The data show that Hoe 140 inhibits scalding and carrageenan oedema for more than four and six hours, respectively. Based on its potency against actions of endogenously generated kinins Hoe 140 is appropriate to investigate the role of kinins in human inflammatory diseases.

摘要

新型高效B2缓激肽（BK）拮抗剂Hoe 140被测试了抑制烫伤和角叉菜胶诱导的大鼠爪水肿的能力。数据显示，Hoe 140分别抑制烫伤和角叉菜胶引起的水肿超过4小时和6小时。基于其对内源性生成的激肽作用的效力，Hoe 140适合用于研究激肽在人类炎症性疾病中的作用。

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