Damas J, Remacle-Volon G
Institut Léon Fredericq, Université de Liège, Belgium.
Eur J Pharmacol. 1992 Jan 28;211(1):81-6. doi: 10.1016/0014-2999(92)90266-7.
We studied the influence of Hoe 140, a bradykinin antagonist, on inflammatory reactions induced in rats. Hoe 140 reduced paw oedema induced by bradykinin alone, bradykinin plus prostaglandin (PG) E1, carrageenan, urate crystals or urate crystals plus captopril. The inhibitory effect of Hoe 140 lasted for at least 4 h. Hoe 140 also reduced plasma exudation in sponges implanted in the back of the rat. However it did not modify paw oedema induced by zymosan or by heating the paw at 55 degrees C for 30 s. Carrageenan oedema developed to a small extent in kininogen-deficient rats while the swelling induced by heating the paw of kininogen-deficient rats was the same as that measured in normal animals. Hoe 140 had no effect on the slight swelling induced by carrageenan in kininogen-deficient rats. We conclude that the kinin system is involved in inflammatory reactions induced by carrageenan, urate crystals, sponge implantation but not by zymosan and scalding.
我们研究了缓激肽拮抗剂Hoe 140对大鼠体内诱导的炎症反应的影响。Hoe 140可减轻单独使用缓激肽、缓激肽加前列腺素（PG）E1、角叉菜胶、尿酸盐结晶或尿酸盐结晶加卡托普利所诱导的爪部水肿。Hoe 140的抑制作用持续至少4小时。Hoe 140还可减轻植入大鼠背部海绵中的血浆渗出。然而，它并未改变由酵母聚糖或在55摄氏度下将爪部加热30秒所诱导的爪部水肿。在激肽原缺乏的大鼠中，角叉菜胶性水肿有一定程度的发展，而激肽原缺乏的大鼠爪部加热所诱导的肿胀与正常动物所测结果相同。Hoe 140对激肽原缺乏的大鼠中角叉菜胶诱导的轻微肿胀没有影响。我们得出结论，激肽系统参与了由角叉菜胶、尿酸盐结晶、海绵植入所诱导的炎症反应，但不参与由酵母聚糖和烫伤所诱导的炎症反应。
