Adam Jean François, Elleaume Hélène, Joubert Aurélie, Biston Marie Claude, Charvet Anne Marie, Balosso Jacques, Le Bas Jean François, Estève François
Equipe d'accueil Rayonnement synchrotron et recherche médicale, Université Joseph Fourier, European Synchrotron Radiation Facility, Grenoble, France.
Int J Radiat Oncol Biol Phys. 2003 Dec 1;57(5):1413-26. doi: 10.1016/j.ijrobp.2003.07.007.
Enhancement of the radiation dose delivered to a brain tumor can be achieved by infusing an iodinated contrast agent to the patient and irradiating with kilovoltage X-rays in computed tomography (CT) mode. Synchrotron sources, providing monochromatic tunable intense beams, are ideal for this treatment. The aim of this study is to assess in vivo the efficiency of this novel radiotherapy modality, Synchrotron Radiation CT-Therapy.
Intracranial implantations of 10(5) F98 glioma cells were performed on 18 Fisher 344 rats. Six rats were untreated controls, six received radiotherapy alone (10 Gy in the tumor by single fraction tomographic irradiation at 50 keV), and six received the same radiotherapy treatment under a continuous infusion of iodinated contrast agent.
The rats that received contrast agent during radiotherapy survived significantly longer than rats that received radiotherapy alone (p = 0.025). Mean survival times (mean +/- SD) were 12.3 +/- 0.8, 14.8 +/- 2.8, and 18.2 +/- 1.3 days; median survival times were 12.5, 15, and 18 days (untreated controls, irradiated without iodine, irradiated with iodine, respectively). The increase in life spans was 20% and 44% for the rats irradiated without or with iodine, respectively.
This method of radiation dose enhancement in brain tumors with synchrotron radiation significantly increases survival and appears highly promising.
通过向患者输注碘化造影剂并在计算机断层扫描（CT）模式下用千伏级X射线进行照射，可提高输送至脑肿瘤的辐射剂量。同步加速器源能提供单色可调强光束，是这种治疗的理想选择。本研究的目的是在体内评估这种新型放射治疗方式——同步辐射CT治疗的效率。
对18只Fisher 344大鼠进行颅内植入10(5)个F98胶质瘤细胞的操作。6只大鼠为未治疗对照组，6只仅接受放射治疗（通过在50 keV下进行单次断层照射使肿瘤接受10 Gy照射），6只在持续输注碘化造影剂的情况下接受相同的放射治疗。
在放射治疗期间接受造影剂的大鼠存活时间明显长于仅接受放射治疗的大鼠（p = 0.025）。平均存活时间（平均值±标准差）分别为12.3±0.8、14.8±2.8和18.2±1.3天；中位存活时间分别为12.5、15和18天（未治疗对照组、未用碘照射、用碘照射）。未用碘或用碘照射的大鼠寿命延长分别为20%和44%。
这种利用同步辐射增强脑肿瘤辐射剂量的方法显著提高了存活率，似乎极具前景。
