卡铂颅内递送联合 6 MV 光子或单能同步加速器 X 射线对 F98 大鼠神经胶质瘤的治疗同样有效。
Intracerebral delivery of carboplatin in combination with either 6 MV photons or monoenergetic synchrotron X-rays are equally efficacious for treatment of the F98 rat glioma.
机构信息
INSERM U836 Équipe 6, Grenoble Institut des Neurosciences, Grenoble, France.
出版信息
J Exp Clin Cancer Res. 2012 Sep 20;31(1):78. doi: 10.1186/1756-9966-31-78.
BACKGROUND
The purpose of the present study was to compare side-by-side the therapeutic efficacy of a 6-day infusion of carboplatin, followed by X-irradiation with either 6 MV photons or synchrotron X-rays, tuned above the K-edge of Pt, for treatment of F98 glioma bearing rats.
METHODS
Carboplatin was administered intracerebrally (i.c.) to F98 glioma bearing rats over 6 days using AlzetTM osmotic pumps starting 7 days after tumor implantation. Radiotherapy was delivered in a single 15 Gy fraction on day 14 using a conventional 6 MV linear accelerator (LINAC) or 78.8 keV synchrotron X-rays.
RESULTS
Untreated control animals had a median survival time (MeST) of 33 days. Animals that received either carboplatin alone or irradiation alone with either 78.8 keV or 6 MV had a MeSTs 38 and 33 days, respectively. Animals that received carboplatin in combination with X-irradiation had a MeST of > 180 days with a 55% cure rate, irrespective of whether they were irradiated with either 78.8 KeV synchrotron X-rays or 6MV photons.
CONCLUSIONS
These studies have conclusively demonstrated the equivalency of i.c. delivery of carboplatin in combination with X-irradiation with either 6 MV photons or synchrotron X-rays.
背景
本研究的目的是比较卡铂 6 天输注，随后用 6MV 光子或同步加速器 X 射线进行 X 照射的疗效，X 射线调谐到铂的 K 边缘以上，用于治疗 F98 神经胶质瘤荷瘤大鼠。
方法
在肿瘤植入后 7 天，通过 AlzetTM 渗透泵向 F98 神经胶质瘤荷瘤大鼠颅内（i.c.）给予卡铂，持续 6 天。在第 14 天，使用传统的 6MV 线性加速器（LINAC）或 78.8keV 同步加速器 X 射线单次给予 15Gy 的放疗。
结果
未治疗的对照组动物中位生存时间（MeST）为 33 天。单独接受卡铂或单独接受 78.8keV 或 6MV 照射的动物 MeST 分别为 38 和 33 天。接受卡铂联合 X 射线照射的动物 MeST>180 天，治愈率为 55%，无论它们接受 78.8keV 同步加速器 X 射线还是 6MV 光子照射。
结论
这些研究明确证明了卡铂颅内给药联合 6MV 光子或同步加速器 X 射线照射的等效性。
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