Adam Jean-François, Joubert Aurélie, Biston Marie-Claude, Charvet Anne-Marie, Peoc'h Michel, Le Bas Jean-François, Balosso Jacques, Estève François, Elleaume Hélène
INSERM U647, Grenoble, France.
Int J Radiat Oncol Biol Phys. 2006 Feb 1;64(2):603-11. doi: 10.1016/j.ijrobp.2005.09.004. Epub 2005 Dec 9.
Heavy-atom-enhanced synchrotron stereotactic radiotherapy (SSR) is a treatment that involves selective accumulation of high-Z elements in tumors followed by stereotactic irradiation with X-rays from a synchrotron source. The purpose of this study was to determine whether the efficacy of iodine-enhanced SSR could be further improved in the F98 rodent glioma model, by using a concomitant injection of an iodinated contrast agent and a transient blood-brain barrier opener (mannitol) during irradiation.
Fourteen days after intracerebral inoculations of F98 cells, the rats were irradiated with 50-keV X-rays while receiving an infusion of hyperosmotic mannitol with iodine, either intravenously or via the carotid (9 to 15 rats per group, 117 rats total).
For doses<or=15 Gy, the intracarotid infusion of mannitol and iodine improved the rats' survival compared with intravenous injection or irradiation alone. The percentage-increased life spans (ILS) were 91%, 116%, and 169% without iodine, after infusion of iodine and mannitol intravenously, and intracarotid, respectively (15 Gy). At 25 Gy, the rats irradiated without iodine had the longest survival (ILS=607%), but no additional benefit was obtained with iodine and mannitol.
Iodine-enhanced SSR is significantly improved with concomitant intracarotid infusion of iodine and mannitol for radiation doses<or=15 Gy.
重原子增强型同步加速器立体定向放射治疗（SSR）是一种先让高Z元素在肿瘤中选择性聚集，然后用来自同步加速器源的X射线进行立体定向照射的治疗方法。本研究的目的是通过在照射期间同时注射碘化造影剂和短暂开放血脑屏障的药物（甘露醇），来确定在F98啮齿动物胶质瘤模型中碘增强型SSR的疗效是否能进一步提高。
在脑内接种F98细胞14天后，给大鼠注射50keV的X射线，同时通过静脉或颈动脉输注含碘的高渗甘露醇（每组9至15只大鼠，共117只大鼠）。
对于剂量≤15Gy，与单独静脉注射或照射相比，经颈动脉输注甘露醇和碘可提高大鼠的生存率。在15Gy剂量下，无碘组、静脉输注碘和甘露醇组、经颈动脉输注碘和甘露醇组的寿命延长百分比（ILS）分别为91%、116%和169%。在25Gy剂量下，未用碘照射的大鼠存活时间最长（ILS=607%），但碘和甘露醇并未带来额外益处。
对于≤15Gy的放射剂量，经颈动脉同时输注碘和甘露醇可显著提高碘增强型SSR的疗效。
