由慢性淋巴细胞白血病患者的淋巴细胞选择的具有Ia特异性的抗血清。

Antisera with Ia specificity selected by lymphocytes from patients with chronic lymphocytic leukemia.

作者信息

Lawler S D, Dewar P J, Mrazek I, Jones E H, Hockley A B

出版信息

Vox Sang. 1978;34(4):200-7. doi: 10.1111/j.1423-0410.1978.tb02468.x.

DOI:10.1111/j.1423-0410.1978.tb02468.x

Abstract

Cells from patients with chronic lymphocytic leukaemia (CLL) have been used to screen the sera of pregnant women for antibodies specifc for B lymphocytes. The sera have been divided into groups showing Ig specificity: group I (UK 3) had a positive association with HLA-B8 and DW3, and group II (UK 2) with HLA-B7 and DW2. Groups III, IV and X were independent of each other and of HLA-A, B and C locus antigens. Certain sera with B-cell activity showed specific blocking activity in the mixed lymphocyte reaction (MLR), and this activity was dependent on the Ia sepcificities and DW specificities of cells used in the MLR. Some sera specifically blocked the responding cells, other the stimulating cells.

摘要

慢性淋巴细胞白血病（CLL）患者的细胞已用于筛查孕妇血清中针对B淋巴细胞的特异性抗体。血清已根据Ig特异性分组：I组（UK 3）与HLA - B8和DW3呈正相关，II组（UK 2）与HLA - B7和DW2呈正相关。III组、IV组和X组彼此独立，且与HLA - A、B和C位点抗原无关。某些具有B细胞活性的血清在混合淋巴细胞反应（MLR）中表现出特异性阻断活性，且该活性取决于MLR中所用细胞的Ia特异性和DW特异性。一些血清特异性阻断反应细胞，另一些则阻断刺激细胞。