Monteagudo Carlos, Fernández-Figueras Maria Teresa, San Juan Josefina, Lopez Dolores, Carda Carmen
Departamento de Patología, Universidad de Valencia, Valencia, Spain.
Am J Dermatopathol. 2003 Dec;25(6):485-9. doi: 10.1097/00000372-200312000-00005.
Melanocytic matricoma is a recently described lesion characterized by well-circumscribed nodules composed of matrical and supramatrical cells with clustered ghost cells, and admixed pigmented dendritic melanocytes, with no cyst formation or connection to the epidermis or pre-existing hair follicles. Although variable cytologic atypia and frequent mitoses in the epithelial component may be present, given the well-defined margins and absence of tumor recurrences, these lesions were initially considered benign neoplasms, and not matrical carcinoma. Theoretically, the detection of numerous melanocytes in matrical carcinoma should not be surprising, but is in fact a very unusual feature. A case with extensive melanization of epithelial elements and only rare melanocytes has been reported. We report two cases of matrical carcinoma with prominent melanocytic hyperplasia, with emphasis on the ultrastructural and immunohistochemical features. Our cases might be considered the malignant counterpart of the so-called melanocytic matricoma.
黑素细胞性基质瘤是一种最近才被描述的病变，其特征为边界清楚的结节，由基质细胞和基质上细胞组成，伴有成簇的影细胞，并混有色素性树突状黑素细胞，无囊肿形成，与表皮或原有的毛囊无连接。尽管上皮成分中可能存在不同程度的细胞异型性和频繁的核分裂，但鉴于边界清晰且无肿瘤复发，这些病变最初被认为是良性肿瘤，而非基质癌。从理论上讲，在基质癌中检测到大量黑素细胞并不令人惊讶，但实际上这是一个非常不寻常的特征。曾有一例报道，上皮成分广泛黑素化，仅见罕见的黑素细胞。我们报告两例伴有显著黑素细胞增生的基质癌病例，重点阐述其超微结构和免疫组化特征。我们的病例可能被视为所谓黑素细胞性基质瘤的恶性对应物。
