Ardakani Nima Mesbah, Palmer David L G, Wood Benjamin A
*Department of Anatomical Pathology, PathWest Laboratory Medicine, QEII Medical Centre, Perth, Australia; †Histology Unit, Western Diagnostic Pathology, Perth, Australia; and ‡School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia.
Am J Dermatopathol. 2016 Jan;38(1):33-8. doi: 10.1097/DAD.0000000000000329.
To describe 2 cases of melanocytic matricoma with malignant histological features and systematically review previously reported cases of malignant melanocytic matricoma.
Two cases of malignant melanocytic matricoma were identified from the practice of the authors. Additional 3 cases were identified in the literature. The clinical and pathological features of these 5 cases are described.
Malignant melanocytic matricoma occurs predominantly in sun-damaged skin of elderly individuals. The tumor is composed of atypical epithelial cells with brisk mitotic activity showing evidence of matrical keratinization and widespread positivity with beta-catenin. There is an admixed cytologically bland dendritic melanocytic component. To date, local recurrence has occurred in one case, but no cases of disseminated disease or death have been reported.
Recognition of this rare tumor and separation from a range of diagnostic mimics is important to ensure adequate treatment by local excision and to allow further cases to be identified to better define the biological potential of this lesion.
描述2例具有恶性组织学特征的黑素细胞性毛母质瘤，并系统回顾先前报道的恶性黑素细胞性毛母质瘤病例。
从作者的临床实践中识别出2例恶性黑素细胞性毛母质瘤。在文献中又识别出另外3例。描述这5例病例的临床和病理特征。
恶性黑素细胞性毛母质瘤主要发生于老年人受阳光损伤的皮肤。肿瘤由具有活跃有丝分裂活性的非典型上皮细胞组成，显示出毛母质角化的证据，且β-连环蛋白广泛阳性。存在混合的细胞学上温和的树枝状黑素细胞成分。迄今为止，1例出现局部复发，但未报道有播散性疾病或死亡病例。
认识这种罕见肿瘤并与一系列诊断性模仿病变相鉴别，对于确保通过局部切除进行充分治疗以及识别更多病例以更好地界定该病变的生物学潜能非常重要。
