Tsujino H, Jones M, Shiota T, Qin J X, Cardon L A, Morehead A J, Zetts A D, Bauer F, Stiges M, Hang X, Greenberg N L, Panza J A, Thomas J D
Cardiovascular Imaging Center, The Cleveland Clinic Foundation, Cleveland, USA.
Comput Cardiol. 2000;27:761-4.
Real-time, 3D color Doppler echocardiography (RT3D) is capable of quantifying flow at the LV outflow tract (LVOT). However, previous works have found significant underestimation for flow rate estimation due to finite scanning time (ST) of the color Doppler. The authors have, therefore, developed a mathematical model to correct the impact of ST on flow quantification and validated it by an animal study. Scanning time to cover the entire cross-sectional image of the LVOT was calculated as 60 ms, and the underestimation due to temporal averaging effect was predicted as 18 +/- 7%. In the animal experiment, peak flow rates were obtained by spatially integrating the velocity data front the cross-sectional color images of the LVOT. By applying a correction factor, there was an excellent agreement between reference flow rate by an electromagnetic flow meter and RT3D (angstroms=-5.6 ml/s, r=0.93), which was significantly better than without correction (p<0.001). Real-time, color 3D echocardiography was capable of quantifying flow accurately by applying the mathematical correction.
实时三维彩色多普勒超声心动图（RT3D）能够对左心室流出道（LVOT）的血流进行定量分析。然而，先前的研究发现，由于彩色多普勒有限的扫描时间（ST），流量估计存在显著低估。因此，作者开发了一个数学模型来校正ST对血流定量的影响，并通过动物研究对其进行了验证。覆盖LVOT整个横截面图像的扫描时间计算为60毫秒，由于时间平均效应导致的低估预测为18±7%。在动物实验中，通过对LVOT横截面彩色图像的速度数据进行空间积分来获得峰值流速。通过应用校正因子，电磁流量计的参考流速与RT3D之间具有极好的一致性（偏差=-5.6毫升/秒，r=0.93），这明显优于未校正时的情况（p<0.001）。实时三维彩色超声心动图通过应用数学校正能够准确地对血流进行定量分析。
