Althoff J, Grandjean C, Gold B, Runge R
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1977 Dec 15;90(3):221-5. doi: 10.1007/BF00284295.
The effect of 1-oxopropylpropylnitrosamine (1-OPPN) was examined in Syrian hamsters. The subcutaneous (s.c.) LD50 was 308 mg/kg b.w. Animals treated s.c. once with a high dose of 1-OPPN had subcutaneous sarcomas and vaginal papillomas. Weekly s.c. injections for life led to high incidences of sarcomas at the injection site. In addition, 1-OPPN had a systemic effect. Neoplasms developed in the nasal cavity, larynx, trachea, lungs forestomach, and vagina. The results are discussed in connection with those found with other DPN derivatives substituted in the alpha-position.
研究了1-氧代丙基丙基亚硝胺（1-OPPN）对叙利亚仓鼠的影响。皮下（s.c.）半数致死剂量（LD50）为308毫克/千克体重。用高剂量1-OPPN皮下注射一次的动物出现了皮下肉瘤和阴道乳头瘤。终生每周皮下注射导致注射部位肉瘤的高发病率。此外，1-OPPN具有全身作用。鼻腔、喉、气管、肺、前胃和阴道均出现肿瘤。结合在α位被取代的其他二丙基亚硝胺衍生物的研究结果对这些结果进行了讨论。
