二正丙基亚硝胺、β-羟丙基正丙基亚硝胺和甲基正丙基亚硝胺对斯普拉格-道利大鼠的致癌作用。
Carcinogenic effects of Di-n-propylnitrosamine, beta-hydroxypropyl-n-propylnitrosamine, and methyl-n-propylnitrosamine on Sprague-Dawlay rats.
作者信息
Reznik G, Mohr U, Krüger F W
出版信息
J Natl Cancer Inst. 1975 Apr;54(4):937-43.
PMID:1127723
Abstract
The carcinogenic effects of di-n-propylnitrosamine and its two related compounds, beta-hydroxypropyl-n-propylnitrosamine (HPPN) and methyl-n-propylnitrosamine (MPN), were tested in rats and compared. All three substances induced neoplasms in the nasal and paranasal cavities, esophagus, and liver. MPN treatment caused the highest tumor incidence in the esophagus, whereas HPPN induced the most hepatic tumors.
摘要
对二正丙基亚硝胺及其两种相关化合物β-羟基丙基正丙基亚硝胺（HPPN）和甲基正丙基亚硝胺（MPN）的致癌作用在大鼠身上进行了测试并加以比较。所有这三种物质均在鼻腔、鼻窦、食管和肝脏诱发了肿瘤。MPN处理导致食管中的肿瘤发生率最高，而HPPN诱发的肝脏肿瘤最多。
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